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《Journal of South China University of Technology(Natural Science Edition)》 2008-04
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Effect of Low-Power Millimeter Wave Radiation on Gene Expression Profile of HL60 Leukemia Cell

Lai Huang-wen1 Jiang Yue-hua2 Zhang Hong-bin2 Lai Sheng-li1 Wang Jie2 Wu Jie2(1.School of Electronic and Information Engineering,South China University of Technology,Guangzhou 510640,Guangdong,China;2.Center of Medical Research,General Hospital of Guangzhou Military Command,Guangzhou 510010,Guangdong,China)  
In this paper,the gene chip technology was adopted to reveal the difference in gene expression profile between the HL60 leukemia cells exposed to millimeter wave(MMW) at 41.32GHz and the sham-exposed group.The gene expressions of IL-7,EGF and LGALS3 were then confirmed by means of RTR-PCR method.The results show that,after the MMW radiation for 60min,HL60 cells proliferate and 18 up-regulated genes and 306 down-regulated genes are found,and that the down-regulated genes of IL-7,EGF and LGALS3 obtained by RT-PCR method are consistent with those obtained by gene chip technology.It is thus concluded that the radiation of MMW promotes the proliferation of HL60 cells by altering the gene expression profile.
【Fund】: 广东省科技发展基金资助项目(2002C31101);; 广东省自然科学基金资助项目(990587)
【CateGory Index】: R733.7
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