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Studies on the Acute and Genetic Toxicity of Mefenacet on D.rerio

JIANG Gang-cheng1,SHAN Guang-fu2 (1.Xuchang University,Xuchang 461000,China;2.Henan Educational Institute,Zhengzhou 450003,China)  
In this paper,the effects of acute and genetic toxicity induced by mefenacet on D.rerio was investigated.The results showed that the mefenacet can poison D.rerio in some conditions.The LC50 of mefenacet at 24h and 48h are 0.058mL/L and 0.019mL/L,respectively.The highest frequencies of micronucleus of control group was 0.0167%,while that of the experimental group was 0.0434%.At some concentrations,mefenacet can induce significant increases in the frequencies of micronucleus.There was distinct difference in comparison with the control group.We also found that the concent ration and time have significant correlation with the frequencies of micronuclei,while the frequencies of micronuclei declined obviously in the highest concentration group.This indicated that the mitotic rate of cells also influences the frequencies of micronuclei.
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