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《Journal of Natural Science of Hunan Normal University》 2017-04
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Cesium-Catalyzed Highly Regio-and Stereo-Selective Synthesis of S(Se)-Substituted Tegafur Alkenes

TAN Ping;LUO Xiang-gui;XU Xin-hua;Hunan Mechanical Electrical Polytechnic;Hunan Academy of Mechanical Sciences;College of Chemistry and Chemical Engineering,Hunan University;  
Tegafur alkynes are synthesized by using tegafur and 3-(p-toluene sulfonyl) propyne as starting materials,which were then treated with diaryl disulfides or diaryl diselenides catalyzed by cesium hydroxide monohydrate to yield S(Se)-substituted tegafur alkenes in high regio-and stereo-selectivity.This method has the advantages of environmentally friendly,high yield,mild conditions and high regio-and stereo-selectivity,providing a convenient and efficient way to obtain S(Se)-substituted tegafur alkenes,which could be used as effective drugs for cancer treatment in the future.
【Fund】: 湖南省教育厅科学研究资助项目(14C0405)
【CateGory Index】: TQ460.6
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