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《Journal of Zhengzhou University(Science Medical)》 1984-03
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Studies on the chronic toxicity of bimolane (AT-1727)

Wang Qingduan, et al Pharmacologic Department, Henan Medical Institute  
Bimolane (AT-1727), bis[N-morpholinomethyl--Piperazinedine 1, 2-bis (3, 5-dioxopiperazinyl)-ethane], is a derivative of ICRF--154.Expe-riments showed that this compound was an effective antineoplastic agent.In view of long-term administration of this drug, its chronic toxicity onrats was studied. Experiments showed that no effect on weight, bone mar-row, liver and kidney functions was noted in the rats administered dailythrough the intragastric route for 9 months at the total dosege of 2,925mg/kg and 5,850mg/kg respectively. Histological examinations of the vitalorgans (such as heart, liver, lung, kidney, spleen, intestine and stomach)showed no definite pathological changes.
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【References】
Chinese Journal Full-text Database 1 Hits
1 Wang Qingduan;Jiang Jinhua;Sun Wenxin;Xia Wei (Henan Institute of Medical Sciences,Zhengzhou450052);Study on acute and long-term toxicity of crude flovone of pueraria lobata[J];JOURNA OF HENAN MEDICAL UNIVERSITY;1999-02
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Chinese Journal Full-text Database 1 Hits
1 Zhang Tanmu,Chen Zhengyu and Linchen(Department of Pharmacoogy Henan Medical Institute,Zhengzhou);PHARMACOLOGICAL STUDIES ON BIMOLANE(AT-1727), A NEW ANTINEOPLASTIC AGENT[J];Acta Pharmaceutica Sinica;1980-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 KX Xue, S Wang, GJ Ma, GQ Wang, JZ Wu Cancer institute of Jiangsu Province, Nanjing Bimolane (AT-1727), 1, 2-bis (4-morpholinomethyl-3, 5-;STUDIES ON CHROMOSOMAL ABERRATION AND MICRONUCLEUS FORMATION IN HUMAN LYMPHOCYTES INDUCED BY BIMOLANE[J];Carcinogenesis,Teratogenesis and Mutagenesis;1990-02
2 WANG Mian-ying WANG Qeng-duan YE Qi-xia LI Goudong LIU Teng-xian ZHANG Tan-mu(Department of pharmacology, Henan Medical inst. Zhengzhou);EFFECTS OF AT-1727(bimolane) AND AT-2153(probimane) ON THE CONTENT OF CYTOCHROME P_(450) IN RAT LIVER MICROSOME[J];Chinese Journal of Cancer;1988-04
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1 Yang Wenxian ,et al Henan Tumuitr Institute,Zhengzhou, 450003;Experimental Study on the Traditional Chinese Drug R in the Prevention of NSAR-Induced Cancer of the Proventriculus in Mice[J];;1992-02
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