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A comparative study of the clinical effect of clozapine and chlorpromazine on schizophrenia type Ⅰ

Wang Changhong;Lin Yunling;Lu Xiuyun;Zhao Xingfu(Henan Provincial Mental Diseases Hospital,Xinxiang 453002)  
A comparatve study was carried out on the therapeutic effects and the adverse reactions of the two antipsychotic drugs,clozapine and chlorpromazine on 76 females with schizophrenia type Ⅰ(40 treated with clozapine,and 36 with chlorpromazine).Symptomatic changes were tested with SANS and SAPS,and side effects with TESS,The patients were followed up for 1~3 years.The results showed that the clinical effect of clozapine was better than that of chlorpromazine on schizophrenia type Ⅰ.Its recurrent rate was lower than that of chlorpromazine's and the side effects of the two drugs were different.It is concluded that clozapine is safe and effective for schizophrenia type Ⅰ.The pathophysiological meehanism of the genesis of schizophrenia type Ⅰ has been discussed with a review of the relevant literatures.
【CateGory Index】: R749.305
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