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《JOURNA OF HENAN MEDICAL UNIVERSITY》 1994-01
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Determination of metoprolol in plasma with high performance liquid chromatography

Ji Biansheng;Zhang Yindi(Department of Pharmacology, Henan Medical University,Zhengzhou 450052 Department of Pharmacology,Nanjing Medical College, Nanjing 210029)  
High performance liquid chromatography was used together with a RF-530 fluoresence detector.The column of 30 mm×40 mm containing octadecylsilance of 5μm(produced in Dalian,China)as reserved phase was used as solid phase.The mobile phase delivered at 1 ml/min was prepared by mixing tetrahydrofuran and water.Atenolol was used as internal standard.The detector was operated at 284 nm excitation and 302 nm emission wave lengths. The detection limit of metoprolol was 5 ng or 20 ng/ml in plasma.The within-day recovery rate and CV% were 99.8±1.84% and 1.84 and those of between days were 99.4±3.75% and 3.77,respectively.In view of its advantages of selectivity,simplicity,rapidity,and accuracy,the method is suitable for clinical pharmacological research.
【CateGory Index】: R914.1
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【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Zhou Danhong Zhang Shumin He Chunxian Guo Ying Wang Xiuling * (Department of Chemistry,Liaoning Normal University Dalian 116029);DETERMINATION OF METOPROLOL TARTRATE NITROSO DERIVATIVE BY SINGLE SWEEP OSCILLOPOLAROGRAPHY[J];JOURNAL OF LIAONING NORMAL UNIVERSITY(NATURAL SCIENCE EDITION);1998-01
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 SUN Jianhua1),LI Haixia2),ZHANG Hongling2,3),XU Bingxin2),ZHANG Zhenzhong2,3)1)Department of Pharmacy,371rd Central Hospital of PLA,Xinxiang 453000 2)College of Pharmacy,Zhengzhou University,Zhengzhou 450001 3)Henan Key Laboratory of Molecular Medicine,Zhengzhou 450052;Capillary electrophoresis determination of metoprolol tartrate tabCapillary electrophoresis determination of metoprolol tartrate tablets[J];Journal of Zhengzhou University(Medical Sciences);2008-06
2 LI Sha1,WANG Xing-li1,FU Shao-lian1,LI Lin-lin1,WANG Kai-yu1,SONG Yan1,LI Xiao-fei1,MA Zhi-guo1,ZHAO Wen2(1.Department of Pharmaceutics;2.Analytical and Testing Center,College of Pharmacy,Jinan University,Guangdong Guangzhou 510632,China);HPLC-UV method for the determination of metoprolol in rabbit plasma and its application in pharmacokinetic study[J];Chinese Journal of Hospital Pharmacy;2012-10
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