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《Journal of Chinese Practical Diagnosis and Therapy》 2013-05
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Relationship of osteopontin and renal function with the severity of coronary artery lesions

CHEN Jian,CEHN Yu,TANG Yong,HUANG Xiao-hong,CHEN Man-tian,ZHOU Qing, ZHANG Ya-chen,SHEN Cheng-xing,LI Yi-gang(Department of Cardiology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)  
Objective To explore the relationship of plasma osteopontin level and renal function with the severity of coronary artery lesions.Methods Osteopontin level and renal function were detected and compared in 210 patients with coronary heart disease(CHD group) and 134 patients without coronary heart disease(control group) to analyze the relationship of osteopontin and renal function with the severity of coronary artery lesions.Results The levels of plasma osteopontin and creatinine were significantly higher in CHD group than those in control group(P0.01),and estimated glomerular filtration rate was lower in CHD group than that in control group(P0.01).The proportions of single-vessel lesion and normal renal function were lower in patients with high osteopontin than those in patients with low osteopontin(P0.05),and the proportion of multi-vessel lesion was higher in patients with moderate and severe decreased renal function than that in patients with normal renal function(P0.05).Osteopontin and renal insufficiency were the independent risk factors for coronary heart disease.Conclusion Plasma osteopontin level is associated with renal insufficiency,both of which are correlated with the severity of coronary artery lesions.
【CateGory Index】: R541.4
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