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《Journal of Chinese Practical Diagnosis and Therapy》 2013-05
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Heart protection effect of low-dose aspirin on diabetic rats

GONG Hui,WANG Gao-pin,LIU Yi(Department of Pharmacology,Liaoning Medical University,Jinzhou 121001,China)  
Objective To explore the effect of low-dose aspirin on heart protection in diabetic rats and its mechanism.Methods Male SD rats were intravenously injected 30 mg/kg streptozotocin by tail to establish type 1 diabetes animal models,and were randomly divided into diabetes model group(diabetes group) and aspirin treatment group(aspirin group),with 8 rats in each group.And another 8 healthy male SD rats were as controls(control group).Aspirin group received oral administration of 9 mg/kg aspirin + distilled water,control group and diabetes group received the same amount of distilled water.After 12 weeks,fasting plasma glucose(FPG),serum creatine kinase(CK) and lactate dehydrogenase(LDH) levels were detected in these three groups.The pathological microstructure of myocardial tissue was observed with HE dyeing method.The expressions of caspase-3,Bax and Bcl-2 were detected with immunohistochemical method.Results The levels of FPG,CK and LDH were significantly higher in diabetes group and aspirin group than those in control group(P0.05).The level of FPG was significantly lower in aspirin group than that in diabetes group(P0.05).The levels of CK and LDH were higher in aspirin group than those in diabetes group,but there was no significant difference(P0.05).The heart microstructure of rats was basically normal,with pathological changes such as local myocardial fibers derangement in diabetes group,which was improved after small-dose aspirin treatment for 12 weeks.The levels of caspase-3 and Bax were higher,the level of Bcl-2 was lower,and the Bcl-2/Bax ratio was lower in diabetes group compared with control group(P0.05).The levels of caspase-3 and Bax were lower,the level of Bcl-2 was higher,and the Bcl-2/Bax ratio was obviously higher in aspirin group compared with diabetes group(P0.05).Conclusion Low-dose aspirin may protect heart in diabetic rats by regulating the expression of apoptosis-related proteins.
【CateGory Index】: R587.1
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