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《Hunan Journal of Traditional Chinese Medicine》 2015-01
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SOFA- based evaluation of prognostic impact of detoxicating and stasis- resolving granules in patients with severe chronic hepatitis

LONG Fu-li;MAO De-wen;CHEN Xiao-ming;ZHANG Rong-zhen;YANG De-fen;YI Min-ming;XU Gang;The First Affiliated Hospital of Guangxi University of Chinese Medicine;  
Objective: To observe the prognostic impact of detoxicating and stasis- resolving( DTSR) granules in severe chronic hepatitis patients with different Sequential Organ Failure Assessment( SOFA) scores. Methods: A total of92 patients with severe chronic hepatitis who met the diagnostic criteria were selected and were randomly divided into treatment group( n = 46) and control group( n = 46) according to the SOFA scores before treatment. The treatment group received DTSR granules and basic Western medicine treatment,while the control group received basic Western medicine treatment alone. The SOFA scores before and after treatment were recorded and subjected to comparative analysis. Results: The treatment group had a significantly lower maximum SOFA score than the control group( P 0. 05). After treatment,the surviving patients had a significantly lower SOFA score than the dead patients[( 6. 23 ±2. 87) vs( 9. 53 ± 2. 86),P 0. 001) ]. Conclusion: The mortality of patients with severe chronic hepatitis rises with increasing SOFA score. DTSR granules can significantly decrease the SOFA score in patients with severe chronic hepatitis,further proving that the prescription can improve the prognosis and reduce the mortality of patients.
【Fund】: 广西壮族自治区卫生厅自筹课题(编号:Z2012155);; 广西中医药大学普通课题(编号:P2012045)
【CateGory Index】: R285.6
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