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《Hunan Journal of Traditional Chinese Medicine》 2015-01
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Association between TCM syndromes and serum IL- 1β level in patients with knee osteoarthritis

JIANG Sheng-chang;TANG Hao;ZHANG Xin-cheng;QIU Xiang-zhong;WANG Wei;ZHU Cheng-xun;The Affiliated Hospital of Hunan Academy of Chinese Medicine;  
Objective: To investigate the association between serum IL- 1β level and traditional Chinese medicine( TCM) syndromes in patients with knee osteoarthritis. Methods: The prospective study included 90 patients with knee osteoarthritis,who were divided into three groups according to different TCM syndromes( deficiency of liver and kidney and tendon- vessel stasis; deficiency of spleen and kidney and dampness infusion into bone and joints; deficiency of liver and kidney and phlegm- blood accumulation),with 30 cases in each group. In addition,30 healthy volunteers without knee osteoarthritis,endocrine diseases,and other diseases aged over 40 years were selected as normal control group. Serum interleukin- 1β( IL- 1β) levels were determined and compared between these groups. Results:( 1) Distribution of TCM syndromes: Of the 90 patients with knee osteoarthritis,37( 41. 1%) had syndromes of deficiency of liver and kidney and tendon- vessel stasis,28( 31. 1%) had syndromes of deficiency of spleen and kidney and dampness infusion into bone and joints,and 25( 27. 8%) had syndromes of deficiency of liver and kidney and phlegm- blood accumulation.( 2) Patients with knee osteoarthritis had significantly higher serum IL- 1β levels than the normal control group( P 0. 01); among patients with knee osteoarthritis,serum IL- 1β was lowest in those with syndromes of deficiency of liver and kidney and phlegm- blood accumulation and highest in those with syndromes of deficiency of liver and kidney and tendon- vessel stasis,and there was significant difference between the two groups( P 0. 05); there was no significant difference in serum IL- 1β level between patients with syndromes of deficiency of spleen and kidney and dampness infusion into bone and joints and patients with syndromes of deficiency of liver and kidney and phlegm- blood accumulation or syndromes with deficiency of liver and kidney and tendon- vessel stasis( P 0. 05). Conclusions: For patients with knee osteoarthritis,serum IL- 1β level is related to TCM syndromes and can be used for the auxiliary diagnosis of TCM syndromes.
【Fund】: 湖南省卫生厅中医药科研基金项目(编号:2012155)
【CateGory Index】: R274.9
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