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《Hunan Journal of Traditional Chinese Medicine》 2015-01
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Effects of detoxicating wash on expression of Smad3 and Smad4 in rats with diabetic ulcer

SUN Chang;GAO Tong;ZHAO Quan-lin;Shandong University of Traditional Chinese Medicine;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine;  
Objective: To investigate the effects of detoxicating wash on the expression of Smad3 and Smad4 in the wound granulation tissues of rats with diabetes. Methods: Fifty Wistar rats were treated to establish a model of diabetic ulcer. Eighteen successfully treated rats were randomly divided into three groups: detoxicating wash group,basic fibroblast growth factor( b FGF),and diabetes model group,with 6 rats in each group. Another 10 rats were treated to establish a rat model of ulcer,and the 6 successfully treated rats were set as normal model group. After respective treatments,immunohistochemistry and Western blot were used to measure the expression of Smad3 and Smad4 in wound granulation tissues. Results: The diabetes model group had significantly higher expression of Smad3 and Smad4 than the detoxicating wash group,b FGF group,and normal model group( P 0. 01). The detoxicating wash group had significantly lower expression of Smad3 and Smad4 than the b FGF group( P 0. 05),and there was a significant difference compared with the normal model group( P 0. 05). Conclusion: High expression of Smad3 and Smad4 may be one of reasons that the wound seldom heals in diabetic patients. Detoxicating wash can promote wound healing by down- regulating the expression of Smad3 and Smad4.
【Fund】: 山东省自然科学基金资助项目(编号:2009ZRB02074)
【CateGory Index】: R285.5
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