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《Hunan Journal of Traditional Chinese Medicine》 2015-01
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Effects of detoxicating wash on expression of Smad3 and Smad4 in rats with diabetic ulcer

SUN Chang;GAO Tong;ZHAO Quan-lin;Shandong University of Traditional Chinese Medicine;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine;  
Objective: To investigate the effects of detoxicating wash on the expression of Smad3 and Smad4 in the wound granulation tissues of rats with diabetes. Methods: Fifty Wistar rats were treated to establish a model of diabetic ulcer. Eighteen successfully treated rats were randomly divided into three groups: detoxicating wash group,basic fibroblast growth factor( b FGF),and diabetes model group,with 6 rats in each group. Another 10 rats were treated to establish a rat model of ulcer,and the 6 successfully treated rats were set as normal model group. After respective treatments,immunohistochemistry and Western blot were used to measure the expression of Smad3 and Smad4 in wound granulation tissues. Results: The diabetes model group had significantly higher expression of Smad3 and Smad4 than the detoxicating wash group,b FGF group,and normal model group( P 0. 01). The detoxicating wash group had significantly lower expression of Smad3 and Smad4 than the b FGF group( P 0. 05),and there was a significant difference compared with the normal model group( P 0. 05). Conclusion: High expression of Smad3 and Smad4 may be one of reasons that the wound seldom heals in diabetic patients. Detoxicating wash can promote wound healing by down- regulating the expression of Smad3 and Smad4.
【Fund】: 山东省自然科学基金资助项目(编号:2009ZRB02074)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 QU Ji fu,HAO Li,SUN Wei,et al. (Institute of Combined Injury of PLA,Third Military Medical University,Chongqing 400038,China);Retrospective study on changes of cytokines in processes of wound healing and its significance[J];Journal of Traumatic Surgery;2003-01
2 DI Yanfei, ZHU Xudong, LIU Chen, et al. Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China;Expressions of TGF-β signal transducer molecules Smad3 and Smad4 during wound healing of rats' skin[J];Chinese Journal of Traumatology;2002-07
3 ZHENG Shu-juan ,JIA Chi-yu,QIU Ya-bin,ZHANG Xi. Graduate School of Shanxi Medical University,Taiyuan 030001,China;Effect of fibroblasts in diabetes ulcer wound healing with the treatment of bone marrow mesenchymal stem cells[J];Chinese Journal of Injury Repair and Wound Healing(Electronic Edition);2013-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 DENG Hai-Ping,YU Shi-Yuan,CHEN Yu-Qin,WANG Yu,GUO Ting-Ting FENG Hong-Li,JIA Yan-Fang College of Life Science,Northwest Normal University,Lanzhou 730070,China;Effects of X-ray on postnatal body weight,growth of skin and hair,activities and content of Superoxide Dismutase,Catalase,and Maleic Dialdehyde in liver and kidney of mice[J];Acta Zoologica Sinica;2008-06
2 HU Jian-hua,LI Bang-chun(Department of Orthopaedics,Chongqing Emergency Medical Center,Chongqing 400014.China);Peripheral knee joint fracture or dislocation with popliteal artery trauma[J];Chongqing Medicine;2008-10
3 Cao Bo1,Li Zhi1,Li Shaotang2,Deng Wenling1 (1.Department of Anus & Intestine The First Affiliated Hospital of Guiyang College of Traditional chinese Medicine/ Guizhou Provinal Anorectal Hospital,Guiyang,Guizhou 550001,China;2.Department of Anus & Intestine Shanghai Jiaotong University Affiliated Hospital,Xinhua Hospital,Shanghai 200092,China);Influence of Qi Yu Ointment on the expression of EGF mRNA in Anal Fistula Wound Granulation Tissue[J];Chongqing Medicine;2011-27
4 LIU Su-xiu,LIU Guo-dong, ZHANG Yu(Department of Laboratory Medicine,Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042 .China);Role of integrin signal system in wound healing[J];Journal of Traumatic Surgery;2004-06
5 ZHAO Jing-yu,FU Xiao-bing,CHEN Wei,et al.(Key Research Laboratory of Wound Repair,304th Clinical Department of PLA General Hospital,Beijing 100037,China);Effects of modified acidic fibroblast growth factor on apoptosis in intestinal tissue after ischemia and reperfusion in rats[J];Journal of Traumatic Surgery;2005-06
6 QU Ji-fu,SHI Chun-meng,JIANG De-peng,et al.(Department of Emergency Medicine,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Effects of heat shock protein 70 on wound healing[J];Journal of Traumatic Surgery;2006-06
7 Zhang Bo,An Hongda,Jia Ruigang,et al.Coloproctological Hospital of Xi'an,Xi'an 710016,China;Usage of compound carraghenates cream after operation for anal fissure and perianal abscess:report of 54 cases[J];Journal of Colorectal & Anal Surgery;2007-04
8 LIU Liang,LIU Xu-sheng,ZHANG Xiao-qi,et al.Institute of Burn Research, Southwestern Hospital, The Third Military Medical University , State Key Laboratory of Trauma, Burn and Combined Injury,Chongqing 400038,China;Influence of Active Macrophages on the Vascular Endothelial Biological Characteristics and the VEGF Receptor mRNA and α ν β_3 Expression[J];Journal of Chinese Physician;2003-11
9 ;Clinical management of burns or skin ulcers in patients with diabetes mellitus[J];Academic Journal of Second Military Medical University;2004-10
10 XIAO Hai-jun,HOU Chun-lin~(*),LIU Ya-ping(Department of Orthopedics,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China);Effect of carboxymethylchitosan on autocrine growth factor and morphology of fibroblasts cultured in vitro[J];Academic Journal of Second Military Medical University;2006-08
China Proceedings of conference Full-text Database 3 Hits
1 LIU Qi, YAN Jian, XIONG Nan-Shan, HU Yue-Jun, LIU Tao* The 457th Hospital of PLA WU HAN 430012;Clinic effect of artificial cell healing membrane with the epidermal growth factor on the treatment of skin defects[A];[C];2009
2 LIU Qi,YAN Jian,XIONG Nan-Shan,HU Yue-Jun,LIU Tao The 457th Hospital of PLA WU HAN 430012;Clinic effect of artificial cell healing membrane with the epidermal growth factor on the treatment of skin defects[A];[C];2010
3 jiang Jinsong Department of Vascular Surgery,Zhejiang Provincial People's Hospital,Hangzhou,310014,China.;Acute iliac and femoral vascular injuries:reports of 29 cases[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 ZHONG Xiao-hong,WANG Ming-gang,ZHAO Li-ping,GAO Xin-yu (Department of Plastic Surgery,the Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,Anhui,China);Preliminary study on differentiation of bone marrow mesenchymal stem cells into epidermal cells in diabetic wound[J];Chinese Journal of Aesthetic Medicine;2010-01
2 QU Ji-fu,CHENG Tian-min,XU Lin-shui,et al.Institute of Combining Injury,Third Military Medical University,Chongqing 400038,China;Effects of radiation on fibroblasts and their significances[J];Modern Rehabilitation;2001-22
3 Li Qiang,Li Wei-jia,Huang Ying Department of Hematology,First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China;Application of mesenchymal stem cells in the treatment of aplastic anemia[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-06
4 YAO Min XU Weishi SHI Jixiang Burn Institute,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025;Gene expression of growth factors and their receptors in healing of partial thickness burn wound in rats[J];;1999-02
5 FU Xiao bing, SUN Tong zhu, WANG Ya ping, et al.The 304th Hospital of PLA. Beijing, P.R.China 100037;COMPARATIVE STUDY OF EPIDERMAL GROWTH FACTOR AND BASIC FIBROBLAST GROWTH FACTOR ON WOUND HEALING[J];CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY;1999-05
6 LIU Jing*,HAN Dong-mei,WANG Zhi-dong,XUE Mei,ZHU Ling,YAN Hong-min,GUO Zi-kuan,WANG Heng-xiang.*Department of Hematology,General Hospital of the Air Force,Beijing 100142,China;Clinical analysis of umbilical cord mesenchymal stem cells in treatment of spinal cord injury[J];Chinese Journal of Injury Repair and Wound Healing(Electronic Edition);2011-04
7 TIAN tian, JIA Chi-yu. Center of Plastic Surgery and Burn Repair, the 309th Hospital of Chinese People’s Liberation Army, Beijing 100091, China;Current study of bone marrow-derived mesenchymal stem cells differentiation into vascular endothelial cells in tissue repair[J];Chinese Journal of Injury Repair and Wound Healing(Electronic Edition);2012-04
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