Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Hunan Journal of Traditional Chinese Medicine》 2015-01
Add to Favorite Get Latest Update

Comparative study on Wittig- Horner reaction and Grignard reaction in synthesis of resveratrol derivative

LIU Qiang;SHENG Wen-bing;LIU Wen-bin;LIN Shi-sang;JI Jie;PENG Cai-yun;Hunan University of Traditional Chinese Medicine;  
Objective: To conduct a comparative study on the synthesis of the resveratrol derivative 3,4,5,4'- tetramethoxystilbene. Methods: The 3,4,5- trimethoxybenzoic acid and anisaldehyde were selected as raw materials and were treated by Na BH4 reduction and SOCl2 halogenation to obtain halogenated hydrocarbons,which were subjected to Wittig- Horner reaction and Grignard reaction to obtain Wittig agent and Grignard agent,respectively. The Wittig agent and Grignard agent were separately mixed with anisaldehyde for condensation to obtain 3,4,5,4'- tetramethoxystilbene. The structure of final product was identified by 1H- nuclear magnetic resonance(1H- NMR) and mass spectrometry( MS). Results:1H- NMR and MS showed that the overall yields of 3,4,5,4'- tetramethoxystilbene synthesized by Wittig- Horner reaction and Grignard reaction were 75. 76% and 15. 96%,respectively,with a significant difference. Conclusion: Compared with Grignard reaction,Wittig- Horner reaction is more favorable for the formation of double bonds in the key steps of preparation of target compound and ensures higher yield and lower cost. Wittig-Horner reaction is more suitable for the complete synthesis of target compound.
【Fund】: 湖南省中医药管理局科研项目(编号:2012163);; 2013年度湖南省大学生创新性实验计划项目(编号:174);; 湖南省药学重点学科资助(编号:2011)
【CateGory Index】: R284.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 WANG Ya-ning,WEI Ya-hui,HAO Hao-yong,JI Jing-yuan (Key Laboratory of Resource Biology and Biotechnology in Western China,College of Life Science,Northwest University,Xi'an 710069,China);Advances in the Research of Resveratrol Metabolins[J];Acta Botanica Boreali-Occidentalia Sinica;2007-04
2 NIE Lei,YE Min-yi,LIN Jing-hui,HUANG Xiao-chan,FENG Xin-jun(Guangzhou City Polytechnic,Guangzhou 510405);Effects of Resveratrol and Sodium Nitroprusside on Preservation of Cut Rose[J];Journal of Guangzhou City Polytechnic;2009-01
3 GAO Cai-qin;FAN Yong;DAI Hong-jun;WANG Zhen-ping;Grape and Wine Education Department Technology Research Center,Ningxia University;;Effect of SA on the Accumulation of Resveratrol in Carbernet-Sauvignon Grape[J];Northern Horticulture;2014-06
4 JIN Hong;HUI Wei;NIU Rui-xue;Industry and Trade of Anhui Vocational and Technical College;College of Life Sciences,Shanxi Normal University;Institute of Science and Technology Information of Gansu;;Preservation Agent and Inhibitory Effects of Resveratrol on Superficial Scald of Dangshan Pear[J];Journal of Huaibei Normal University(Natural Science Edition);2014-01
5 LI Hai-qing1,2,3,LIU Xu2,3,WANG Qing-guo2,3,YAO Fang-yin2,3,LIU Wei1,2,3(1.High-Tech Research Center,Shandong Academy of Agricultural Sciences,Key Laboratory of Crop GeneticImprovement and Biotechnology,Shandong Province,Jinan 250100,China;2.Key Laboratory of Crop GeneticImprovement and Biotechnology,Huanghuaihai,Ministry of Agriculture,Jinan 250100,China;3.College of Life Sciences,Shandong Normal University,Jinan 250014,China);Construction of Biosafe Vectors of Resveratrol Synthase Gene and Rice Genetic Transformation[J];Acta Agriculturae Boreali-Sinica;2011-02
6 XIA Hai-wu,TAN Zhi-jing,MIAO Yong-mei,DENG Dun(Anhui Science and Technology University,Fengyang 233100,China);Determination of Resveratrol in Polygonum cuspidatum by HPLC[J];Hubei Agricultural Sciences;2011-04
7 PENG Yuan-de1,ZHU Zuo-hua1,LIU Zheng-chu1,DUAN Sheng-wen1,LI Zhi-min1,YAN Li1, QIN Lian-cheng2,WEI Jie-zhong2(1.Institute of Bast Fiber Crops,Chinese Academy of Agricultural Sciences,Changsha 410205,China; 2.Huayuan Hengyuan Plant Biochemical Co.,Ltd.,Huayuan 416400,Hunan,China);Study on Extraction of Resveratrol from Polygonum cuspidatum by Yeast Fermentation[J];Hubei Agricultural Sciences;2011-23
8 WANG Qiu-an,WANG Li,ZOU Liang-hua,ZHANG Zhuo-jia (College of Chemistry and Chemical Engineering,Hunan Univ,Changsha Hunan 410082,China);Studies on the Synthesis of New Resveratrol Derivatives[J];Journal of Hunan University(Natural Sciences);2009-07
9 Peng Caiyun1,4,Xiao hao2,Cheng Wenming3,Kuang Chao2,Yao Lili2,Yan Xiaozhi2,Wang Zhengtao2(1.Hunan university of TCM pharmacy,changsha,hunan 410208;2.Traditional Chinese Medicine University,Changsha 410007;3.Hunan medical university graduate,hunan changsha level in 2009 410007,China;4.Hunan provincial key discipline and hunan province of hunan TCM furiher study key laboratory,changsha,hunan 410208);The research of resveratrol[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2010-08
10 ZHANG Cai-yun1,2,KANG Xiang-tao1,3(1.College of Animal Husbandry and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450002,China;2.Department of Bio-engineering,Henan University of Technology,Zhengzhou 450001,China;3.Henan Innovative Engineering Research Center of Poultry Germplasm Resource,Zhengzhou 450002,China);Effects of dietary resveratrol on antioxidant ability and meat quality in broilers[J];Jiangsu Journal of Agricultural Sciences;2011-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Lan-sheng,LIU Guang-ming(College of Pharmacy,Dali University,Dali,Yunnan 671000,China);Reviews of reseach on resveratrol[J];Journal of Dali University;2007-04
2 Li Dingzhong,Cai Anan,Wei JianKe,You Yi,Gong Fuchun(College of Chemistry and Biological Engineering,Changsha University of Science and Technology,Changsha;Synthesis of 3,4-Dimethoxy Phenethylamine Based on KBH_4/F_3B-Et_2O Reduction System[J];Guangdong Chemical Industry;2010-02
3 SHEN Yanyan1,MIAO Huaming1,2,XU Jingkun1,ZHANG Honglin2,LU Baoyang1(1 Jiangxi Key Laboratory of Organic Chemistry,Jiangxi Science and Technology Normal University,Nanchang 330013)(2 Department of Chemistry Science,Qufu Normal University,Qufu 273165);ELECTROPOLYMERIZATION OF CARBAZOLE IN MIXED ELECTROLYTE OF TETRAHYDROFURAN AND BORON TRIFLUORIDE DIETHYL ETHERATE[J];Acta Polymerica Sinica;2008-11
4 JIANG Ming-lian,LI Zhi-fei Nanning Institute for Food and Drug Control,Nanning 530001,China;Study on process of separating Resveratrol from GentrinKentrin with membrane separation technique and the determination[J];Acta Medicinae Sinica;2008-04
5 Guo Jingnan 1 ,Liu Chonghuai 1 ,Pan Xing 1 ,and Wang Jishuan 2 ( 1 Zhengzhou Fruit Research Institute,CAAS,Zhengzhou,Henan450009; 2 Yanshi Agricultural Science and Technology Extension Centre,Yanshi,Henan471900);Advances in Research on Resveratrol in Vitis spp.[J];Journal of Fruit Science;2002-03
6 Guo Bin,Wei Yahui ,Cao Wei Department of Biology,Northwest University,Xi′an 710069,China;BREEDING VARIETY CELLS OF RESCERATROL BY He-Ne LASER INDUCED[J];Acta Photonica Sinica;2002-03
7 LUO Li, HUANG Yi-ming~ (Deparment of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078,China);Effect of resveratrol on the cognitive ability of Alzheimer’s mice[J];Journal of Central South University(Medical Sciences);2006-04
8 LAN Tian-lu,ZHU Hong-ji,LI Shao-bai(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China);Extraction of Resveratrol from Giant knotweed with Enzymolysis-Microwave[J];Chemical Industry and Engineering;2008-05
9 ZHANG Min, CAO Yong, Yu Hua-zhong, TANG Wan-yong, YAN Yan (Forest Products Chemical Engineering Key Laboratory of Hunan Province,Jishou University,Zhangjiajie,427000,China);PRELIMINARY STUDY ON EXTRACTION PROCESS OF RESVERATROL FROM PLOYGONUM CUSPIDATUM[J];Journal of Chemical Industry of Forest Products(Bimonthly);2004-03
10 Liu Shuxing1,Cheng Liying1,Geng Wei2,Tang Muhong1,Wu Xin1 (1. College of Life Science & Engineering,Shaanxi University of Science & Technology,Xianyang,Shaanxi 712081, China; 2. Xianyang Institute of Supervision & Testing on Product Quality,Xianyang,Shaanxi 712000,China);Study on the Purification of Resveratrol by HSCCC[J];;2005-Z2
Similar Journals
> Chemical World
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved