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Effects of berberine combined with evodiamine on liver HMG- CoA reductase and L- FABP mRNA expression levels in a rat model of hyperlipidemia

WANG Jing;LIN Jing-jing;SHEN Tao;Chengdu University of Traditional Chinese Medicine;  
Objective: To observe the effects of berberine combined with evodiamine on liver HMG-CoA reductase and L- FABP mRNA expression levels in a rat model of hyperlipidemia and to investigate the lipid- lowering mechanism. Methods: A total of 40 healthy male Sprague- Dawley rats were equally and randomly divided into normal control group,model control group,simvastatin group,and low- and high- dose berberine combined with evodiamine groups. The rat model of hyperlipidemia was established using high- fat emulsion. The relative expression levels of liver HMG- CoA reductase and L- FABP mRNA were measured using RT- PCR with 18 sRNA as a reference gene in these different groups. Results: Berberine combined with evodiamine significantly reduced the HMG- CoA reductase and L- FABP mRNA levels,and the high- dose group had greater reductions in the two indices. Conclusion:Berberine combined with evodiamine can reduce blood lipid level in the rat model of hyperlipidemia and its mechanism may be related to the inhibition of liver HMG- CoA reductase and L- FABP mRNA expression levels.
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