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Clinical effect of different formulas of Jiawei Danshen decoction in treatment of myocardial ischemia- reperfusion injury

CHEN Cong;DAI Yu-wei;TAN Kai-yun;REN Ting;HUANG Zheng-de;LIAO Jing;Hunan University of Chinese Medicine;The First Affiliated Hospital of Hunan University of Chinese Medicine;  
Objective: To investigate the optimal formula of Jiawei Danshen decoction in the treatment of myocardial ischemia- reperfusion injury( IRI) in rats and the traditional Chinese medicine( TCM) treatment of myocardial IRI. Methods: The model of myocardial ischemia / reperfusion( IR) was established by ligation of the left anterior descending coronary artery. With lactate dehydrogenase( LDH) and creatine kinase( CK) as markers,an orthogonal test was designed to investigate the effect of pretreatment with various formulas of Jiawei Danshen decoction on the serum levels of LDH and CK. Results: Compared with the blank group,the Jiawei Danshen decoction group showed significant reductions in the serum levels of LDH and CK( P 0. 05). The comparison of different formulas showed that Salvia miltiorrhiza,Astragalus membranaceus,Paeoniae Radix Rubra,and Carthamus tinctorius had the most significant effects. The comparison of range between each group showed that Salvia miltiorrhiza had the greatest effect on the serum levels of LDH and CK,followed by Astragalus membranaceus,Paeoniae Radix Rubra,and Carthamus tinctorius. Conclusion: Jiawei Danshen decoction can significantly reduce the serum levels of LDH and CK. Salvia miltiorrhiza,Astragalus membranaceus,Paeoniae Radix Rubra,and Carthamus tinctorius play important role in this formula,and the qi- tonifying and blood- activating method can alleviate myocardial IRI.
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