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《Chemical Reaction Engineering and Technology》 2002-01
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Study on the Synthesis and Using of 2-Amino-5-Methylthiazole

RU De xin (College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China)  
amino 5 methylthiazole (1) was prepared using 1,2,3 trichloropropane as starting material, which reacted with sodium hydroxide to get 2,3 dichloro 1 propene ,which reacted with potassium thiocyanide, then via isomerization and reacted with ammonia hydroxide, and at last through cyclization. The overall yield was increased from 24.6% to 41.3%. and Meloxicam(6) was also synthetised by the condensation with 2 amino 5 methylthiazole(1) and the intermediate (5) of piroxicam.
【Key Words】: amino 5 methylthiazole meloxicam
【CateGory Index】: TQ463
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WU Ying,CHEN Hong,YANG Long-sheng (Department of Chemical and Material Engineering, Hefei University,Hefei 230022,China);Quantitative Analysis of Butyl p-Hydroxybenzoate by Gas Chromatography[J];Anhui Chemical Industry;2007-02
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5 She Yuanbin; Huang Ying; Wang Xiaoyi; Song Xufeng; Chen Yuyun (College of Environment and Energy Engineering, Beijing Polytechnic University, Beijing, 100022 )Yang Jinzong(The State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian;Studies on Synthesis and Separation of p-Hydroxybenzaldehyde[J];JOURNAL OF BEIJING POLYTECHNIC UNIVERSITY;1999-03
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7 Liu Yuping; Sun Baoguo; Tian Hongyu; Zhang Jun (Department of Chemical Engineering, Beijing Institute of Light Industry, Beijing 100037);THE SYNTHSIS OF Di-n-PROPYL TETRASULFIDE[J];JOURNAL OF BEIJING INSTITUTE OF LIGHT INDUSRY;1998-03
8 SHENG Shou-ri, LIU Xiao-ling, CHENG Cai-xia, SONG Cai-sheng (Institute of Chemistry and Biological Sciences,Jiangxi Normal University,Nanchang 330027,China);Catalytic Synthesis Methyl Chloroacetate with the Sulfonated Poly(Aryl Ether Ketone Ketone) Resin[J];Journal of Jiangxi Normal University (Natural Sciences Edition);2001-04
9 XU Jing Shi, ZHOU Guo Bin, WANG Hong Ming, CHEN Hui Zong (Institute of Chemistry and Biology Sciences,Jiangxi Normal University,Nanchang 330027,China);Study on Synthesis of Hydroxybenzoic Esters with TiO_2/SO_4~(2-) Solid Acids Zeolites as Catalyst[J];Journal of Jiangxi Normal University (Natural Sciences Edition);2002-01
10 YU SHan-xin 1 WEN Rui-ming 2 LONG Li-ping 1 (1.Department of Chemistry and Chemical engineering, Hunan Normal University,Changsha Hunan,410081) (2.Department of Chemistry,Hunan Urban College, Hunan Yiyang 413049);CATALYTIC SYNTHESIS OF n-BUTYL LACTATE WITH SOLID ACID[J];Journal of Changde Teachers University;2003-01
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