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《Chemical Reaction Engineering and Technology》 2002-01
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Study on the Synthesis and Using of 2-Amino-5-Methylthiazole

RU De xin (College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China)  
amino 5 methylthiazole (1) was prepared using 1,2,3 trichloropropane as starting material, which reacted with sodium hydroxide to get 2,3 dichloro 1 propene ,which reacted with potassium thiocyanide, then via isomerization and reacted with ammonia hydroxide, and at last through cyclization. The overall yield was increased from 24.6% to 41.3%. and Meloxicam(6) was also synthetised by the condensation with 2 amino 5 methylthiazole(1) and the intermediate (5) of piroxicam.
【CateGory Index】: TQ463
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