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《West China Journal of Stomatology》 2014-01
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Inhibitory effects of high mobility group chromosomal protein N2 on human tongue carcinoma transplanted in nude mice

Liu Xiqian;Dong Xiaoqian;Zhang Yonghong;Zhang Ping;Li Xiaoyu;Chen Sixiu;Feng Yun;State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University;  
Objective To evaluate the inhibitory effect of high mobility group chromosomal protein N2(HMGN2) on human tongue carcinoma tumor in nude mice. Methods A transplantation tumor model in nude mice was constructed by injecting Tca8113 cells. After a week, negative control groups, masculine control groups, and HMGN2 groups were established. Cell culture of the three groups were separately injected with washing buffer Ⅱ, cis-dichlorodiamineplatinum(DDP), and HMGN2 protein. The tumors were moved after four treatments, and then analyzed by hematoxylin-eosin(HE) staining. Results A transplanted tumor model was established successfully. The volumes of HMGN2 groups and masculine control groups were smaller than those of the negative groups. Mouse weight did not differ among the three groups. Average tumor weight of the negative group was(0.38±0.19) g, that of the HMGN2 group was(0.21±0.15) g, and that of the DDP group was(0.23±0.16) g. These factors indicated no statistically significant difference among the three groups. The tumor inhibitory rate of HMGN2 group was 45.71%, and that of the positive group was 39.44%. Based on evaluation by naked eye, the tumor in the negative group was larger than that in other groups. In addition, cell necrosis was observed during HE staining. ConclusionHMGN2 could significantly inhibit growth of the transplanted tumor in nude mice.
【Fund】: 国家自然科学基金资助项目(30972764)
【CateGory Index】: R739.86
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Feng Yun, Xiong Wen-Bi, Wang Guo-Xing, Huang Ning, Wu Qi, Bao Lang, Li Xuan, Wang Bo-Yao** (Research Unit of Infection and Immunity, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China);Identification of HMGN2 as an Effector Molecule of Human LAK Cells[J];Progress In Biochemistry and Biophysics;2005-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Cai Yu-bing(Department of Otolaryngology-Head and Neck Surgery,Xishui People's Hospital,Hubei Province,Huanggang 438200,China);Different Level of HMGB1 and ENA-78 before and after the Treatment of Patients with Sudden Deafness[J];Chinese Journal of Medicinal Guide;2013-07
2 Mu Pingping;Song Hui;Sun Qinfeng;Dept. of Periodontics,Hospital of Stomatology,Shandong University,Shandong Provincial Key Laboratory of Oral Biomedicine;;High-mobility group protein box 1 and periodontal disease[J];International Journal of Stomatology;2014-01
3 LI Hong-min;WANG Jing;HAN Qin;LIU Xin;LENG Yan-bing;HUANG Ning;School of Public Health,Chengdu Medical College;Research Unit of Infection and Immunity,West China Center of Medical Sciences,Sichuan University;;The Influence of P53siRNA on the HMGN2 Expression in Lung Adenocarcinoma Cancer Cells A549[J];Journal of Chengdu Medical College;2014-06
4 ZHANG Min1*,FENG Yun2(1.Pharmacy Department of Sichuan Provincial People's Hospital,Sichuan Academy of Medical Sciences,Chengdu 610072; 2.State Key Laboratory of Oral Diseases,Sichuan University,Chengdu 610041,China);Isolation and purification of HMGN2 from human monocyte cell line THP-1 and its antimicrobial activity[J];Basic & Clinical Medicine;2013-02
5 Zhang Min,Feng Yun,Xiong Wen-bi,Lu Hui-xia,Huang Ning,Wang Bo-yao,Wu Qi (Research Unit of Infection and Immunity,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu,610041,China);Isolation and purification of antimicrobial polypeptide HMGN2 from human monocyte cell line THP-1[J];Sichuan Journal of Physiological Sciences;2006-03
6 Li Wei1 Zhang Ping2 Kong Xiangli2 Li Yan2 Chen Sixu2 Feng Yun2 Wu Qi3 Wang Boyao31(Department of Dermatovenereology,West China Hospital,Sichuan University,Chengdu 610041,China)2(State Key Laboratory of Oral Diseases,Sichuan University,Chengdu 610041,China)3(Research Unit of Infection and Immunity,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China);Isolation and Purification of Antimicrobial Polypeptide HMGN2 from Human Lymph Node and Analysis of its Distribution[J];Journal of Biomedical Engineering;2010-04
7 Zhao Guojun;Yu Hong;Huang Junxing;Department of Oncology,Taizhou City People's Hospital Affiliated to Nantong University;;Research advances of HMGB1 in esophageal squamous cell carcinoma[J];Journal of Modern Oncology;2014-10
8 YUAN Baohong;LIU Danyan;LIU Xiaonan;Department of Anesthesiology, First Affiliated Hospital of Chongqing Medical University;;Progress of high mobility group protein B1 in neuropathic pain[J];Journal of Clinical and Pathological Research;2014-02
9 LI De-chao;ZHOUYan-peng;WANG Ze;Department of Oral Implantology,Affiliated Stomatology Hospital of Jiamusi University;;Expression of interleukin-18 and matrix metalloprotease-13 in peri-implantitis patients[J];Chinese Journal of Practical Stomatology;2014-04
10 ZHANG Min;ZHANG Yuan;TONG Rong-sheng;Pharmacy Department of Sichuan Provincial People's Hospital,Sichuan Academy of Medical Science;;Isolation and purification of antimicrobial polypeptide HMGN2 from human monocyte cell line THP-1 and detecting of its antiviral activity against hepatitis B virus[J];Chinese Journal of Hospital Pharmacy;2014-17
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