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《West China Journal of Stomatology》 2014-01
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Effect of carbon monoxide releasing molecule on experimental periodontitis in rats

Wei Lingling;Hou Meng;Wang Ping;Song Hui;Dept. of Pediatric Dentistry, School of Stomatology, Shandong University;Shandong Provincial Key Laboratory of Oral Biomedicine;Dept. of Specific Diagnosis, School of Stomatology, Shandong University;  
Objective To evaluate the effects of carbon monoxide releasing molecule-2(CORM-2) on experimental periodontitis in rats. Methods Forty-two Wistar rats were divided into three groups. Rats in the normal group(NL group) did not undergo any procedure, whereas the other rats were ligatured and treated with saline solution(NaCl 0.9%)(LO group) or treated with CORM-2(10 mg· kg-1 per day)(CO group). A 3-0 silk suture was placed around the mandibular first molars. Rats were sacrificed after 3, 7, and 10 d. Blood samples were collected from all animals for tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) analysis. Changes in alveolar bone levels were measured clinically, and periodontal tissues were histopathologically examined to assess the infiltration of inflammatory cells. Results Ligature placement increased alveolar bone loss and inflammatory cell infiltration in periodontal tissue. Alveolar bone loss in CO group was significantly higher than that in NL group, but was lower than that in LO group(P0.05). The ratio of inflammatory cell infiltration in LO group was significantly higher than that in CO and NL groups, and that in CO group was lower than in LO group(P0.05). Serum levels of TNF-α and IL-1β in the LO group were significantly higher than those in the CO and NL groups, and those in CO group were lower than in LO group(P0.05). Conclusion Systemic administration of CORM-2 reduced periodontal inflammation and alveolar bone loss in experimental periodontitis in rats.
【Fund】: 山东省自然科学基金资助项目(Y2008C99);; 山东省科技发展计划基金资助项目(2010GSF10270)
【CateGory Index】: R781.4
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhao Huaqiang1,2,Wei Lingling1,3,Hou Meng1,3,Mu Pingping1,3,Wei Fengcai4,Song Hui1,3,Yang Pishan1,3.(1.Shandong Provincial Key Laboratory of Oral Biomedicine,Jinan 250012,China;2.Dept.of Oral and Maxillofacial Surgery,Stomatology Hospital of Shandong University,Jinan 250012,China;3.Dept.of Periodontology,Stomatology Hospital of Shandong University,Jinan 250012,China;4.Dept.of Stomatology,Qilu Hospital of Shandong University,Jinan 250012,China);Influence of carbon monoxide on the expression of adhesion molecules stimulated with tumor necrosis factor-α and interleukin-1β on human gingival fibroblasts[J];West China Journal of Stomatology;2012-03
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 Wang Yanzhi;Li Shu;Dept.of Periodontics,Hospital of Stomatology,Shandong University;Shandong Provincial Key Laboratory of Oral Biomedicine;;Nitric oxide and other gas signaling molecules and periodontal disease[J];International Journal of Stomatology;2014-02
2 YUAN Ju-Fang①,ZHANG Ying-Yu,CHEN Suo-Cheng,TIAN Wei-Feng,SHAO Dong-Hua(①Department of Anesthesiology,②Institute of Cardiovoscular Disease,③Cardio-Thoracic Surgery,Affiliated People's Hospital,Jiangsu University,Zhenjiang 212001,Jiangsu China);Effect of Carbon Monoxide-releasing Molecules in Monocrotaline-induced Pulmonary Hypertension in Rats[J];Pharmaceutical Journal of Chinese People's Liberation Army;2009-01
3 Zhao Huaqiang1,2, Hou Meng3, Wei Lingling3, Mu Pingping3, Song Hui2,3, Yang Pishan2,3. (1. Dept. of Oral and Maxillofacial Surgery, Stomatology Hospital of Shandong University, Jinan 250012, China; 2. Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, China; 3. Dept. of Periodontology, Stomatology Hospital of Shandong University, Jinan 250012, China);Mechanism of carbon monoxide affecting the expression of cellular adhesion molecule under stimulation of inflammatory cytokines to human gingival fibroblasts[J];West China Journal of Stomatology;2013-04
4 SUN Chun-yan;LIN Li;Department of Periodontology,School of Stomatology,China Medical University;;Association of PTX3 in GCF with Chronic Periodontitis[J];Journal of Oral Science Research;2013-11
5 QUAN Yu-feng,ZHENG Ming-ci,ZHANG Hua,OU Wei-lin,ZHANG Pei-lin(Department of Neonatology,the Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi Zhuang Autonomous Region,China);Changes of Expression and Activity of Heme Oxygenase-1 in Peripheral Blood Mononuclear Cell of Hypero-xia-Exposed Premature Infants[J];Journal of Applied Clinical Pediatrics;2011-02
6 Vijith Vijayan, Eveline Baumgart-Vogt, Institute for Anatomy and Cell Biology, Justus-Liebig-University Giessen, 35392 Giessen, Germany Sebastian Mueller, Salem Medical Center and Center of Alcohol Research, University of Heidelberg, 69121 Heidelberg, Germany Stephan Immenschuh, Institute for Transfusion Medicine, Hannover Medical School, 30625 Hannover, Germany;Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract[J];世界胃肠病学杂志(英文版);2010-25
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