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《West China Journal of Stomatology》 2014-01
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Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control of type 2 diabetes patients with moderate to severe periodontitis

Chen Lei;Su Yuan;Ni Jia;Luo Wei;Xuan Dongying;Zhang Jincai;Dept. of Periodontology, Guangdong Provincial Stomatological Hospital, The Affiliated Stomatological Hospital of Southern Medical University;  
Objective To evaluate the effects of periodontal treatment on the clinical response, systemic inflammatory parameters, and metabolic control of type 2 diabetes patients with moderate to severe periodontitis. Methods A total of 56 patients with mean clinical attachment level(CAL)3 mm were included in the subgroup analysis. A repeated-measures ANOVA(group factor: treatment group and control group; time factor: initial visit, 1.5, 3, and 6 months) was used to analyze the probing depth(PD), CAL, bleeding on probing(BOP), high-sensitivity C-reactive protein(hsCRP), glycated hemoglobin(HbA1c), and fasting plasma glucose. Results Significantly lower PD(F=62.898,P=0.000), CAL(F=51.263,P=0.000), BOP(F=75.164,P=0.000), hsCRP(F=6.391, P=0.010), HbA1c(F=4.536, P=0.011), and fasting plasma glucose level(F= 3.073,P=0.031) were observed after therapeutic periodontal improvement. The inter-group differences for PD(t=-2.050, P=0.045), BOP(t=-4.538,P=0.000), and hsCRP(t=-2.261, P=0.028) were statistically significant after therapy. Conclusion Non-surgical periodontal treatment can effectively improve periodontal status, circulating inflammatory status, and metabolic control of diabetic patients with moderate to severe periodontitis.
【Fund】: 科技部“十一五”重点支撑计划基金资助项目(2007BAI-18B02);; 广东省科技计划基金资助项目(2010B031600117)
【CateGory Index】: R781.4
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