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《West China Journal of Stomatology》 2016-04
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Effects of strontium ranelate on the rats' palatal suture after rapid maxillary expansion

Kong Chao;Wang Xuxia;Wang Qianqian;Han Yuanyuan;Zhao Shuya;Zhang Jun;Dept. of Orthodontics,School of Stomatology,Shandong University;Dept. of Oral and Maxillofacial Surgery,School of Stomatology,Shandong University;Key Laboratory of Oral Tissue Regeneration of Shandong Province;  
Objective This study investigated the effects of strontium ranelate(Sr R) on the rats' palatal suture after rapid maxillary expansion(RME). Methods Thirty-six male 6-week-old Wistar rats were randomly divided into three groups: control group(A), expansion only group(B), and expansion plus Sr R group(C). Each group comprised 12 rats. Neither expansion nor Sr R was given to group A. Each rat in groups B and C was set an orthodontic appliance with an initial expansive force of 1 N. The rats in group C were administered with Sr R(600 mg·kg-1 body weight) at the same time every day after RME. All the rats were then euthanized in batches on days 4, 7, and 10. The width of the rats' upper jaw was measured. Histological observation was used to section the rats and count the osteoblasts. Results After the RME, no statistical difference was observed on the rats' upper jaw width in group A(P0.05). However, the change of upper jaw width in groups B and C presented a statistical significance(P0.05). By contrast, no statistical difference was observed between groups B and C(P0.05). The rats' sections were placed under a microscope, and some red fibrous tissues, mesenchymal cells, chondrocytes, and osteoblasts were observed in group A. More red fibrous tissues, mesenchymal cells, and chondrocytes were observed in groups B and C. In addition, more osteoblasts were observed on the edge of mid-palatal suture of the rats. Group C contains more osteoblasts than group B. Conclusion RME can expand the mid-palatal suture of rats, which were in the growth development period, and increase the width of dental arch. Sr R may promote osteoblast differentiation and hasten new bone formation in the expanded mid-palatal suture. Both conditions accelerate new bone formation and bone deposition calcification, which may be therapeutically beneficial to prevent relapse after RME.
【Fund】: 国家自然科学基金(81371180);; 山东省科技发展计划(2014GGH218024)~~
【CateGory Index】: R783.5
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