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《West China Journal of Stomatology》 2016-04
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Analysis of BNIP3 expression and clinical research in salivary adenoid cystic carcinoma

Chen Zhanwei;Sun Dubin;Huang Shengyun;Wu Haiwei;Zhang Dongsheng;Dept. of Oral and Maxillofacial Surgery,Shandong Provincial Hospital Affiliated to Shandong University;Dept. of Stomatology,The People’s Hospital of Zoucheng City;  
Objective This study investigated the expression of BNIP3 in salivary adenoid cystic carcinoma(SACC) and its correlations to the clinicopathological features and prognosis of patients with SACC. The role of BNIP3 in the progress of hypoxia-induced autophagy was elucidated. Methods The expression levels of BNIP3, hypoxia inducible factor(HIF)-1α, and LC3 in 65 SACC cases were detected by immunohistochemical staining method, and the correlation between the expression of BNIP3 and the clinicopathological features in SACC was analyzed. In addition, the correlations of BNIP3 gene expression with HIF-1α and LC3 gene expression were analyzed. The survival rate of patients with SACC was evaluated by univariate survival analysis. Results BNIP3 was considerably expressed in SACC in all three histological patterns, and was positive in 41 cases(63.1%). BNIP3 gene expression was significantly correlated with histological grade(P=0.001) and HIF-1α gene expression(P=0.011). By contrast, BNIP3 gene expression was not significantly correlated with LC3 gene expression(P=0.167). The overall survival rate of patients with negative BNIP3 expression was better than that of patients with positive BNIP3 expression(P0.05). Conclusion BNIP3 might play a vital role in the tumorigenesis of SACC and may be a new target for gene therapy.
【Fund】: 山东省自然科学基金(ZR2012HQ022)~~
【CateGory Index】: R739.8
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 HAN Bo,LI Long-jiang,DAI Wei.(Dept.of Head and Neck Tumor Surgery,West China College of Stomatology,Sichuan University,Chengdu 610041,China);Expression and Significance of Hypoxia Inducible Factor-1α in Buccal Carcinoma[J];华西口腔医学杂志;2007-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Chen Zhanwei;Sun Dubin;Huang Shengyun;Wu Haiwei;Zhang Dongsheng;Dept. of Oral and Maxillofacial Surgery,Shandong Provincial Hospital Affiliated to Shandong University;Dept. of Stomatology,The People’s Hospital of Zoucheng City;;Analysis of BNIP3 expression and clinical research in salivary adenoid cystic carcinoma[J];华西口腔医学杂志;2016-04
2 Wang Bin;Wang Xiaoqin;Dept.of Stomatology, The First Hospital of Shanxi Medical University;;Effects of interleukin-18 and hypoxia-inducible factor-1α in serum and gingival tissues of rat model with periodontitis exposed to chronic intermittent hypoxia[J];华西口腔医学杂志;2015-04
3 YIN Xu-qing1,2,LI Min2 1.Department of Surgery Ⅷ,Shandong Cancer Hospital,Shandong Academy of Medical Sciences,Jinan 250117,P.R.China 2.Department of Traumatology,Zibo Centre Hospital,Zibo 255000,P.R.China;Prognostic value of the expression of HIF-1α and VEGF in malignant fibrous histiocytoma[J];中华肿瘤防治杂志;2012-24
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