Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《West China Journal of Stomatology》 2016-04
Add to Favorite Get Latest Update

Expression and effect of S100A9 in the periodontium of diabetic rats

Sun Wenhua;Chen Guoqing;Tian Weidong;College of Life Science,Sichuan University;State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University;National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University;  
Objective The study seeks to investigate the expression of S100A9 and its potential role in periodontal diseases induced by diabetes. Methods A diabetic SD rat model was established through intraperitoneal injection of streptozotocin(STZ). Hematoxylin-eosin(HE) staining was performed to study the structure of the periodontium of diabetic rats. Using immunohistochemical staining, the distribution of S100A9 expression was detected in the periodontium of diabetic rats. Expressions of Toll-like receptor 4(TLR4)(ligands of S100A9) and p-P65/nuclear factor κB(NF-κB) were also measured. Results The trabecular structure of alveolar bone was sparser, and lamina dura was disappeared in diabetic rats. Obviously higher expressions of S100A9 were observed in the periodontal ligament, alveolar bone, and gingival epithelial of diabetic rats than in the control rats. TLR4 expressions in the periodontal ligament, alveolar bone and gingival epithelial of the diabetic rats were also higher as compared to the control rats. p-P65 expression was not detected in the control rats, but was detected in the periodontal ligament and alveolar bone of the diabetic rats. Conclusion Periodontium lesions in diabetes mellitus may be induced by the activation of TLR4 and NF-κB signaling pathway meditated by S100A9.
【Fund】: 国家自然科学基金(81271119);; 四川省应用基础研究项目(2013JY0019)~~
【CateGory Index】: R587.2;R781.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Wu Xuan1,Liu Hongchen2,E Lingling2,Li Zhenchun1.(1.Dept.of Prosthodontics,Stomatology Hospital of Da-lian City,Dalian 116021,China;2.Stomatology Institute,General Hospital of PLA,Beijing 100853,China);Expression of glucose transporter-1 and insulin receptor α1 in osteoblast obtained from diabetic rats' mandibles[J];华西口腔医学杂志;2011-04
2 LIU Mei1,ZHANG Jun2,WANG Xu-xia3.(1.Dept.of Stomatology,Qilu Hospital,Shandong University,Jinan 250012,China;2.Dept.of Orthodontics,School of Stomatology,Shandong University,Jinan 250012,China;3.Dept.of Oral and Maxillofacial Surgery,School of Stomatology,Shandong University,Jinan 250012,China);A relevant experimental study of alveolar and systemic bone mineral density changes in diabetes rats[J];华西口腔医学杂志;2009-04
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Sun Wenhua;Chen Guoqing;Tian Weidong;College of Life Science,Sichuan University;State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University;National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University;;Expression and effect of S100A9 in the periodontium of diabetic rats[J];华西口腔医学杂志;2016-04
2 YAN Lu;FU Yue;SUN Shang-min;PAN Ya-ping;Department of Endodontics,School of Stomatology,China Medical University;;Effect of diabetes mellitus on tooth wear in rat molars[J];中国实用口腔科杂志;2015-05
3 WU Xuan;LIU Hong-chen;E Ling-ling;Stomatology Hospital of Dalian;;Effect of Insulin on Differentiation of Osteoblasts Obtained from Diabetic Rats' Mandibles[J];口腔医学研究;2014-05
4 GUAN He-yu1,2,LI Xu1(1.China Medial University,Shenyang 110001,Liaoning,China;2.Shenyang Orthopaedics Hospital,Shenyang 110044,Liaoning,China);Study on Changes of TGF-β1 Protein Expression in Osteoporosis of Type Ⅱ Diabetes and Non-Diabetic Rats[J];中华中医药学刊;2012-08
5 LIU Mei1,ZHANG Jun2,WANG Xu-xia3(1.Department of Stomatology,Qilu Hospital,Shandong University,Jinan 250012,China;2.Department of Orthodontics, School of Stomatology,Shandong University,Jinan 250012,China;3.Department of Maxillofacial Surgery,School of Stomatology,Shandong University,Shandong Key Laboratory of Oral Biomedical,Jinan 250012,China);Changes of the mineral density of the alveolar bone between T1DM and T2DM rats[J];山东大学学报(医学版);2011-09
6 Qu Pan,Gao Xiu-qiu Second Affiliated Hospital of Liaoning Medical University,Jinzhou 121000,Liaoning Province,China;Expression of transforming growth factor beta 1 mRNA in alveolar bone of rats with type 2 diabetes mellitus combined with periodontal disease[J];中国组织工程研究与临床康复;2010-46
7 MEI Yin-sheng1,2,JIA Yu-long1,ZHANG Li-na1,JIN Shu-mei1,ZHANG Jun1,3(1.Department of Orthodontics,School of Stomatology,Shandong University,Jinan 250012,China;2.Department of Stomatology,Shandong Crops Hospital of Chinese People′s Armed Police Force,Jinan 250014,China;3.Shandong Provincial Key Laboratory of Oral Biomedicine,Jinan 250012,China);Effect of Dipsacaceae and Salvia on orthodontic teeth movement[J];山东大学学报(医学版);2010-08
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 WU Xuan,LIU Hong-chen,LV Jiao,et al.Stomatology Hospital of Dalian,Dalian 116021;Effect of Insulin on the Glucose Uptake of Osteoblasts Obtained from Diabetic Rats' Mandibles[J];口腔医学研究;2010-03
2 WU Xuan, LIU Hong-chen,MA Wei-dong,E Ling-ling, WANG Dong-sheng (Research Institute of Stomatology, General Hospital of Chinese PLA, Beijing 100853, China);Effect of alloxan-induced diabetes mellitus on the differentiation of osteoblasts obtained from rat mandible in vitro[J];中华老年口腔医学杂志;2008-02
3 Xiao Zhengda,Wang Shufang,Song Zhimin,et al;Relationship among sexhormone,cytokines and bone mineral density in patients with type 2 diabetes mellitus[J];山东医药;2001-23
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved