Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chemistry》 2010-05
Add to Favorite Get Latest Update

Study on the Preparation of Gatifloxacin Imprinted Polymers and its Binding Properties

Ma Jing,Yang Ming ,Zhou Kui,Sheng Xinxin(School of Chemical and Environmental Engineering,Wuhan Polytechnic University,Wuhan 430023)  
Molecular imprinted polymeric microspheres(MIPMs ) were prepared by a one-step swelling polymerization method in an aqueous system using polystyrene microspheres as seeds and Gatifloxacin as template molecules.The recognition mechanism of MIPMs was evaluated by ultraviolet spectrometry.The infrared spectrum of the polymer further demonstrated that there were some functional groups in the MIPMs which could interact with the template molecules.The morphology of the MIPMs was measured by scanning electron microscopy.The binding characteristics were investigated by fluorescence spectrum.Scatchard analysis suggested that there were two classes of binding sites during MIPMs recognition of Gatifloxacin.Equilibrium dissociation constant KD1 and maximum number Bmax1 of binding site with high affinity were calculated to be 0.603 mmol /L and 28.62 μmol /g,while KD2 and Bmax2 of binding site with low affinity were 3.110 mmol /L and 74.27 μmol /g,respectively.
【CateGory Index】: TQ465
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 MIAO Yu shan 1 ,NI Chong 1, NI Tao 2, JIANG Jing yuan 2(1.Zhongda Hospital,Southeast University,Nanjing 210009,China; 2.Nanjing Zhecheng Science Technique Limited Company,Nannjing,210009,China);Determination of gatifloxacin and its related compound in gatifloxacin capsules by RP-HPLC[J];The Chinese Journal of Modern Applied Pharmacy;2003-06
2 Li Qiao, Li Dong, Nie Zhongyue, Xu Yuhong (Shenzhen Futian Hospital, Shenzhen, Guangdong, China 518033; Shenzhen People' s Hospital, Shenzhen, Guangdong, China 518020);Determination of the Content of Gatifloxacin Eye Gel by HPLC[J];China Pharmaceuticals;2006-02
3 Li Hong1,Zhang Li2 (1. Department of Pharmacy,Shenzhen Qilinshan Sanatorium,Shenzhen,Guangdong,China 518055; 2. Shenzhen Nanfang Pharmaceutical Factory of 999 Group,Shenzhen,Guangdong,China 518029);Determination of Related Substances in Gatifloxacin for Injection by HPLC[J];China Pharmaceuticals;2006-03
4 XU Qin, DENG Li-dong (Department of Pharmaceutical Analysis, Guilin Medical College, Guangxi Guilin 541004,China);Study on the determination of gatifloxacin in dog serum by HPLC and its pharmac okinetics[J];Chinese Journal of Hospital Pharmacy;2004-09
5 Zhang Xianzhou,Chen Xiaoli, Han Shiping(Renmin Hospital of Wuhan University, Wuhan 430060,P.R.China);Determination of Gatifloxacin Concentration in Human Plasma by HPLC[J];China Pharmacist;2004-09
Chinese Journal Full-text Database 10 Hits
1 DENG Hong1,LIANG Jian-jian2,ZHANG Shu1,LU Shang-yi(1.Institute of Medica,Guangdong Pharmaceutical University/ Guangdong Provincial Key Laboratory of Advanced Drug Delivery,Guangzhou,Guangdong 510006,China;2.Department of Pharmacy,First People's Hospital of Guangzhou,Guangzhou,Guangdong 510180,China);Determination of gatifloxacin in gatifloxacin-polylactic acid nanoparticles by HPLC[J];Journal of Guangdong College of Pharmacy;2008-03
2 ZHAN Yi,LI Yan-hua(Qingdao Haici Medical Treatment Group,Qingdao 266033,China);Analysis of the Utilization of Antimicrobial Drugs in Qingdao Haici Medical Treatment Group during 2006[J];Food and Drug;2007-08
3 XU Ya-jing1,2,HU Rong-feng1,2,YIN Hui1,2,GAO Yu1,2(1.School of Pharmacy,Anhui College of Traditional Chinese Medicine,Hefei 230031,China;2.Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei 230038,China);Study on gatifloxacin in situ pH-sensitive gel release in vitro[J];Chinese Journal of Biochemical Pharmaceutics;2010-02
4 WANG Yan-dong,TANG Xi-lan,YE Cheng-tian,WU Wei (Zhongshan Ophthalmic Center of Sun Yat-sen University,Guangzhou Guangdong 510060);Determination of Gatifloxacin in Gatifloxacin Eye Drops by RP-HPLC[J];Journal of Modern Food and Pharmaceuticals;2007-02
5 Li Xuchun1,Zhu Hong2(1.Mianyang Central Hospital of Sichuan Province,Mianyang,Sichuan,China 621000;2.Department of Equipment,the First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing,China 400016);Pharmacokinetics of a Single Dose of Oral Gatifloxacin in Beagle Dogs[J];China Pharmaceuticals;2006-10
6 YU Su-hua, MENG Wen-jing, LU Ting-ting, YANG Gong-jun (Sch of Chem & Chem Engin, Yangzhou Univ, Yangzhou 225002, China);Spectrophotometric, spectrofluorimetric and reversed-phase high-performance liquid chromatographic methods for determination of gatifloxacin in its capsule[J];Journal of Yangzhou University(Natural Science Edition);2008-02
7 DENG Lidong, DENG Hang, DENG Jungang, FU Xiang (Dept. of Pharmacy, The Affiliated Hospital of Guilin Medical College, Guilin 541001, China) JANG Xuehua (West-China College of Pharmacy, Sichuan University, Chengdu 610041, China);Comparative Study on in Vivo Pharmacokinetics of Gatifloxacin between Normal Canis Familiaris and Hepatic Injury Model[J];China Pharmacy;2005-21
8 TANG Ling,ZHOU Yuanda,HE Haixia(Clinical Pharmacology Laboratory,The First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing 400016,China);Bioavailability and Bioequivalence of 2 Kinds of Sparfloxacin Capsules in Healthy Subjects[J];China Pharmacy;2007-26
9 Tang Ling,Zhou Yuan-da and He Hai-xia(Clinical Pharmacology Laboratory,the First Affiliated Hospital ofChongqing University of Medical Sciences,Chongqing 400016);Study on the distribution and pharmacokineties of sparfloxacin in ocular tissues after oral administration in rabbits[J];Chinese Journal of Antibiotics;2008-04
10 ZHA NG Sihan et, al (Clinical Pharmacology Laboratory, the First Affiliated Hospital, Chongqing Medical University);The effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae[J];Journal of Chongqing Medical University;2007-12
China Proceedings of conference Full-text Database 1 Hits
1 Wang Yandong, Tang Xilan, Ye Chengtian, Wu Wei (Zhongshan Ophthalmic center of Sun Yat-sen university, guangzhou 510060);HPLC determination of gatifloxacin in compound gatifloxacin eye drop[A];[C];2006
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
2 SHI Yaoguo; ZHANG Jing; YU Jicheng, et al. (Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040, C hina );The clinical pharmacokinetics of gatifloxacin[J];Chinese Journal of Infection and Chemotherapy;2003-05
3 Li Dong 1 ,Zhang Yan 2 ,Chen Xiaokai 3 ,Nie Zhongyue 1 ,Liu Ming 1 ,Gao Guofeng 1 (1.Shenzhen People' s Hospital ,Shenzhen,Guangdong,China 518020;2.Shenzhen Sun Yat -sen Cardiovascu lar Hospital ,Shenzhen,Guangdong,China 518020;3.Shenzhen Futian Hospital ,Shenzhen,Guangdong,China 518033);Study on Stability and Quality Contr ol of Gatifloxacin Gel Eardrops[J];China Pharmaceuticals;2004-08
4 Guo Yanrong,Lu Mei,Zhang Guohong (The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi,China 530021);Determination of Levofloxacin Ophthalmic Gel by HPLC[J];China Pharmaceuticals;2004-12
5 LU Wenyun,ZOU Hao,JIANG Xuetao(The College of Pharmacy,Second Military Medical University,Shanghai200433);Preparation of Fluconazole Adhesive Gel[J];China Pharmacy;2003-10
6 HONG Qing,YUAN Xi,ZHU Shanlan(Dept.of Pharmacy,The First Affiliated Hospital of Fujian Medical University,Fuzhou350005,China) CHENG Qingwei(Fuzhou Institute for Drug Control,Fuzhou350001,China);Preparation and Quality Control of Dibing Gel[J];China Pharmacy;2005-01
7 SUN Tao,SONG Kun-gai,LIN Fu-tian ( Institute of Medicinal Biotechnology,Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing 100050, China )[;The pharmacokinetics of gatifloxacin HCl[J];Chinese New Drugs Journal;2000-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved