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《Chemical Research and Application》 2011-07
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Preparation of electrochemical sensor for paracetamol based on molecular imprinted film

WANG Mao-jun,LIU Cheng-lun,XIE Tai-ping,ZHANG Xiao-min,ZHANG Liu,YANG Qi(College of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400030,China)  
A novel paracetamol electrochemical sensor based on molecular imprinted polymer has been developed.The sensitive layer was prepared by electropolymerization of o-phenylenediamine on a glassy carbon electrode in the presence of the template(paracetamol)which can be removed by ethanol.Square wave voltammetry was applied to investigate the analytical characteristics of the sensor,and indirect analytical method based on the medium of K3[Fe(CN)6]was established.The sensor shows great promise for specific,and sensitive detection of paracetamol.This sensor provided a linear range from 2.0×10-6 to 8.0×10-5mol/L and a detection limit of 2.0×10-8 mol/L.The proposed method was applied to determination of paracetamol in different tablets and the obtained results were satisfactory.
【Key Words】: paracetamol molecular imprinted polymer electrochemical polymerization of o-phenylenediamine sensor
【Fund】: 重庆市科委自然科学基金项目(CSTC 2007BB0200)资助;; 重庆大学“211工程”三期创新人才培养计划项目(S-09103)资助
【CateGory Index】: O657.1;TP212.2
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