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《》 1985-01
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ABNORMAL INSULIN SECRETION AND CARBOHYDRATE METABOLISM IN HYPERCORTISOLISM

Liang Jinzhong;Luo Zhaotian Department of Internal Medicine  
In order to evaluate the disorders of in-sulin secretion and carbohydrate metabolismin hypercortisolism (Cushing's syndrome),changes in both carbohydrate tolerance andinsulin secretion as well as their correlationswith the degree of hypercortisolism werestudied in 62 cases of hypercortisolism (22cases of adrenal adenoma and 44 cases ofadrenal hyperplasia) confirmed by surgicaloperation and pathological findings. Oralglucose tolerance test (OGTT) was carriedout in all the cases and insulin secretoryresponse to glucose load was measured in 9of these cases before operation. A longitudinalobservation of glucose tolerance and insulinsecretion was taken in 5 cases before andafter the surgical treatment. Results showedthat the incidence of glucose intolerancewas 74. 2% (46 cases)in all the cases, with nosignificant difference between cases of adre-nal adenoma and hyperplasia. Twenty-one of62 cases (33. 9%) showed a diabetic OGTTcurve. Twenty-five cases (40. 3%) presentedan impaired OGTT curve but 11 of them hadnormal fasting plasma glucose levels (FPG),indicating that FPG was not a sensitiveindex for detecting abnormal glucose meta-bolism in hypercortisolism. There was anobvious higher insulin secretory response toglucose in hypercortisolism than in normalcontrol (P0.001) and the insulin secretorycurve presented as an delayed and highresponse curve. Successful surgical treatmentmay improve the abnormal insulin response.There seemed to be a well parallel correlationbetween the alleviation of clinical conditionsand the improvement of insulin secretion andcarbohydrate tolerance following the surgicaltreatment.
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【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Feng Kai Lu Zhaolin Zang Meifu Chen Jie Wang Heng (Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China);Clinical Analysis of Glucose Dysbolism in 162 Cases with Cushing Syndrome[J];ACTA ACADEMIAE MEDICINAE SINICAE;2000-03
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