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《Chemistry and Adhesion》 2011-02
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The Preparation and Characterization of Chitosan Sustained Release Microspheres

ZHAO Shu-yan,ZHOU Hao-ran and ZHAO Rui(College of Materials Science and Engineering,Harbin University of Science and Technology,Harbin 150080,China)  
The urea-chitosan sustained release microspheres are prepared with using chitosan,glutaraldehyde and urea as the main raw materials by emulsification-chemical crosslinking method.The structural characteristics of sustained release microspheres are studied by infrared spectra.The micro-morphology of microspheres is observed by scanning electron microscopy.The optimum dosage of glutaraldehyde is determined by the test of cross-linking degree.The sustained release effect is measured by sustained release measurement.The results showed that the chitosan sustained-release microspheres were successfully prepared by emulsification-chemical crosslinking method,the optimum dosage of crosslinking agent was 1mL.Urea in sustained release microspheres released completely after 48h.It indicated that the sustained release microspheres had good sustained release effect.
【CateGory Index】: TQ440.9
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