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《Journal of Harbin Medical University》 2002-01
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Study on telomerase activity in human colorectal carcinoma and metastatic lymph nodes

SONG Sheng han,DONG Xin shu,WANG Xi shan, et al (Department of Abdominal Surgery,The Third Clinical College,Harbin Medical University,Harbin 150040,China)  
Objective To study the telomerase activity in human colorectal carcinoma,tumor adjacent tissue and metastatic lymph nodes and to investigate its clinical value as a parameter for tumor detection.Methods The telomerase activity in samples,including 34 cases of colorectal cancer,20 tumor adjacent tissues and 16 metastatic lymph nodes,was examined by PCR ELISA method based on TRAP assay.Results In colorectal carcinoma,tumor adjacent tissues and metastatic lymph nodes,the expression rate of telomerase activity was 91.2%(31/34),10%(2/20) and 81.3%(13/16) respectively.The telomerase activity in colorectal carcinoma and metastatic lymph nodes was significantly higher than that in tumor adjacent tissues.The positive rate of telomerase activity in colorectal carcinoma had no relation to the patients' sex,age,type of histopathology,area of invasion and Dukes' classification et al.Conclusion The telomerase activity is closely correlated to the generation and evolution of colorectal carcinoma and may be a new target for early diagnosis and therapy.
【CateGory Index】: R735.34
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【Secondary References】
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