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《Journal of Harbin Medical University》 2002-01
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Experiment study on collagen shield carring and releasing dexamethasone

XING Lin,SHAN Fei xue,WANG Xiao dan, et al (Department of Ophthalmology,The First Clinical College,Harbin Medical University,Harbin 150001,China)  
Objective To clarify corneal collagen shield as a drug vehicle for the delivery of dexamethasone and to find the mechanism of such collagen shield compound in ophthalmic topical therapy.Methods 28 white rabbits were randomly divided into four groups by times after using dexamethasone.The left eyes of the rabbits were treated with subconjunctival injection,while the right eyes were treated with collagen shield.At 0.5 ,1,3,5 hours after the treatment,the dexamethsone concentration in aqueous humor of rabbits were measured by high pressure liquid chromatography assay.Results The drug concentrations in the left eye's aqueous humor reached the highest peak at 1 hour(1.8822±0.1289)μg/ml.At 5 hours the drug concentration decreased to (0.0753±0.0111)μg/ml.The dexamethasone concentrations of right eye's aqueous humor began to rise at 1 hour and reached the highest peak at 3 hours(1.0895±0.1392)μg/ml.The drug concentrations still kept at (0.7569±0.1235)μg/ml until 5 hours.Conclusion The corneal collagen shield compoud is a noirritate vehicle for the delivery of dexamethasone,while can play a role in dissolving gradually and maintaining high concentration to the eye.The study provide the scientific basis for demonstrating that the collagen shield used in eye can prolong the effective time of the drug.
【CateGory Index】: R96
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