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《Journal of Harbin Medical University》 2007-04
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Regional abnormal distribution of autonomic nerve and its effect on ventricular function

LI Jing-jie,QU Xiu-fen,SHEN Jing-xia,et al (Department of Cardiology,The First Clinical College,Harbin Medical University,Harbin 150001,China)  
Objective To investigate whether myocardial infarction(MI) can cause heterogeneity of sympathetic innervation and to evaluate the effects of denervation on focal ventricular function.Methods Randomly treated with ligating the left anterior descending coronary artery or sham-operation procedure,14 canines were divided into infarction group and control group.Programmed ventricular stimulation was used to identify sympathetic denervation in noninfarcted myocardium apical to the infarction 4 weeks after infarction.Myocardial contrast echocardialgraphy(MCE) was executed on there,and the focal myocardium microvascular perfusion was detected.Doppler tissue imaging(DTI)was used to evaluate regional ventricular function.Results Shortening of ERP values in response to sympathetic stimulation was presented at all regions of control group but only appeared at the base of the heart in the MI group and there was no significant difference at the apical of the heart before and after sympathetic stimulation,which identified extensive denervation in the left ventricle below the infarct.The systolic velocity and diastolic velocity at both apical and basal regions to the infarction were lower than those in the controal group,But the apical decline proportion compared to the base [(base-apex)/base] was greater than that in the controal group;As for peak intensity(PI) of microbubbles detected by MCE,there was no significant difference of the apical decline proportion compared to the base [(base-apex)/base]between MI group and controal group.Conclusion Regional denervation occurs after MI;Sympathetic denervation may contribute to the dysfunction of regional myocardium after MI.
【Fund】: 国家自然科学基金资助项目(30470687);; 黑龙江省卫生厅科研资助项目(2006-027)
【CateGory Index】: R542.22
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1 ZHANG Run-feng1,3,CHEN Yun-zhen2,TANG Ke-xin3,MA Guo-zhong3, HUANG Xuan-yin3,LUO Zai-gui3,FENG Jin3 1. Post-Doctoral Research Center of Management Science and Engineering, Tongji University, Shanghai 200092, China 2. Department of Cardiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China 3. Third Mianyang People's Hospital, Mianyang 621000, Sichuan Province, China;Effects of Fastigial Nucleus Electro-Stimulation on Cardiac Nerve Regeneration after Myocardial Infarction in Rats Hearts[J];Science & Technology Review;2006-01
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8 XI Yang *,QU Xiu-fen,YU Yan-wei,LI Jing-jie,ZHAO Gang,HUANG Yong-lin. * Department of Cardiology,First Hospital of Harbin Medical University,Harbin 150001,China;Study of sympathetic neural remodeling after myocardial infarction in rats[J];Chinese Journal of Cardiac Arrhythmias;2004-03
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