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《Journal of Harbin Medical University》 2007-04
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Effects of resveratrol on the adhesion,motility and invasion of human mucoepidermoid carcinoma cell line MEC-1 in vitro

GUO Yang,ZHENG Ying-ai,XIE Xiao-hua (Department of Othodontics,The Second Clinical College,Harbin Medical University,Harbin 150081,China)  
Objective To investigate the effects of resveratrol(Res) on the adhesion,motility,and invasion of human mucoepidermoid carcinoma cell line MEC1 in vitro.Methods The adhesion ability of MEC-1 cells was investigated with MTT colorimetric assay.The motility and invasion of MEC-1 cells were assayed by biopore membrane Millicell-PCF inserts culture system.Results The adhesion of MEC-1 cells treated with 100μmol/L Res for 1h or 2h reduced by 23.42% and 34.31%(P0.05),respectively.The motility and invasion of MEC-1 cells treated with 100μmol/L Res reduced by 47.92% and 47.25%(P0.05),respectively.Conclusion Res has an anti-invasion effect on human mucoepidermoid carcinoma cells in vitro,so it may be a potential antineoplastic against tumor invasion or a kind of chemopreventive agent.
【CateGory Index】: R739.8
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