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《Journal of Harbin Medical University》 2007-04
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Association among 5-HT_(1Dβ) receptor gene T371G polymorphism,unipolar depression and symptom phenotype

SHI Mei,AN Gang-hui,XU Ye,et al (Mental Health Institute,The First Clinical College,Harbin Medical University,Harbin 150001,China)  
Objective To investigate the association between 5-HT1Dβ receptor gene T371G polymorphism and unipolar depression(UPD) in Han nationality of Chinese.Methods The case-control association study was adopted to analyze association of the candidate serotonin receptor genes polymorphism between 132 UPD patients and 180 normal controls using PCR-RFLP technique,and evaluate the symptom phenotypes of cases applying HAMD for depression.Results There was significant difference in neither genotype(χ2=0.7478,df=2,P0.05) nor allelic type(χ2=0.2637,df=1,P0.05) distribution between case and control groups.But genotype G/G(1.74±1.25) and T/G(1.61±1.06) scored significantly lower than genotype T/T(2.44±1.19) on diurnal variation,while genotype T/G(7.09±1.93) scored significantly lower than genotype G/G(7.82±1.85) and T/T(8.33±2.22) on hopelessness under HAMD.Conclusion Association is suspected between 5-HT1Dβ receptor gene T371G polymorphism and UPD symptom clusters such as diurnal variation and hopelessness.
【Fund】: 黑龙江省卫生厅科研基金项目(2005-610)
【CateGory Index】: R749.4
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