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《Journal of Harbin Medical University》 2012-01
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Effects of FAP on human umbilical vein endothelial cells proliferation and angiogenesis in vitro

ZHU Lin1,ZHANG Ning2,DAI Hai-li1,SHAO Hong-jiang3 ZHAO Yan1,JIN Zhan-feng1,3(1.Department of Pathology;2.Department of Pathophysiology;3.Department of Forensic Medicine,Harbin Medical University,Harbin 150081,China)  
Objective To investigate the effects of FAP on human umbilical vein endthelial cell proliferation and angiogenesis in vitro.Methods Human umbilical vein endothelial cell EA.hy926 was treated with different concentrations of FAP(0,300,600,1200 pmol/L).Cell proliferation was determined by MTT assay.Cell migration was assessed by a wound healing assay.And tube formation was studied with a three-dimensional gel model.Results Compared with the normal control group,FAP promoted endothelial cell migration and proliferation(P0.05),promoted tube formation of endothelial cell on the gel(P0.01).The effect of 600 pmol/L FAP was significantly higher than that of other groups(P0.01).Conclusion FAP can promote human umbilical vein endothelial cell proliferation,migration and angiogenesis in vitro.It provides a basic theoretical depiction of the role of FAP in angiogenesis.
【CateGory Index】: R361.3
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 GAO Yang1, PENG Xue2, JIN Zhan-fen1,2, FU Zhi-Jun2 (1. Department of Forensic Pathology, Harbin Medical University, Harbin 150081, China; 2. Department of Forensic Medicine, Harbin Medical University, Harbin 150081, China);Expression of FAP and α-SMA During the Incised Wound Healing in Mice Skin[J];Journal of Forensic Medicine;2009-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Zong Ren 1, LI Jing Hua 1, XIAO Tie Hui 1, SHAO Zhong Jun 2, MA Jing 1, ZHENG Jin 1, MA Ai Ling 1, LONG Yin 1, WANG Wen 1, LI Jun Chang 1 1Department of Traditional Chinese Medicine, Xijing Hospital, 2Department of Epidemiology, Facalty of Preventive Medicine, Fourth Military Medical University, Xian 710033, China;Preventive effects of Qidantongmai Tablet on acute myocardial infarction in mice and its influence on expression of VEGF and bFGF[J];Journal of The Fourth Military Medical University;2003-07
2 YUAN Xiang-tian1,PENG Xue2,JIN Zhan-feng2(1.Detachment of Criminal Science and Technology,Public Security Bureau of Hulunbuir,Hulunbuir 021008,China;2.Department of Forensic Medicine,Harbin Medical University,Harbin 150081,China);Expression of FAPα and TGF-β1 in Sudden Deaths due to Acute Myocardial Ischemia[J];Journal of Forensic Medicine;2012-01
3 Huang Qinghong, Cai Weijun1, Wu Song2, Xie Jiying3, Xie Yinggui(Department of Anatomy,Xiangnan College, Chenzhou 423000, China;1Department of Anatomy & Neurobiology, Xiangya School of Medicine , Central South University , Changsha 410013 , China;2Department of Orthopaedics ,Xiangya Third Hospital , Central South University , Changsha 410013 , China;3Affiliated Hospital of Xiangnan College, Chenzhou 423000, China);CHANGES OF MACROPHAGE INVASION DURING COLLATERAL VESSEL GROWTH INDUCED BY ISCHEMIA IN RABBIT HINDLIMB[J];Chinese Journal of Histochemistry and Cytochemistry;2009-01
4 YU Tian-shui1,2,LING Yue3,GUAN Da-wei2(1.Key Laboratory of Evidence Science,Ministry of Education,China University of Political Science and Law,Beijing 100040,China;2.School of Forensic Medicine,China Medical University,Shenyang 110001,China;3.Chongchuan Branch of Nantong Public Security Bureau,Nantong 226006,China);Progress in Myofibroblast and Its Application in Forensic Medicine[J];Journal of Forensic Medicine;2013-02
5 WU Jin-bo,JIN Zhan-feng (Department of Pathology,The Harbin Medical University,Harbin 150080,China);Relationship of FAP Expression with Malignant Biological Behaviors in Gastric Carcinoma[J];Heilongjiang Medical Journal;2008-01
6 SONG Jing1,LI Yue2,WANG Qiu-yan3(1.Department of Obstetrics and Gynecology,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2.Department of Obstetrics and Gynecology,The Hospital of Heilongjiang Province,Harbin 150056,China;3.Department of Obstetrics and Gynecology,Harbin Redcross Central Hospital,Harbin 150076,China);Expression and correlation of fibroblast activation protein and TGFβ_1 in endometrial carcinoma[J];Journal of Harbin Medical University;2011-02
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8 ZHAO Yuan-feng1,2,MENG Gang1,CHEN Lin3(1Department of Pathology,Anhui Medical University,Hefei 230020,China;2Suzhou Municipal Public Security Bureau,Suzhou 234000 China;3Material Evidence Identification & Adminstration Bureau,Hefei 230031,China);Forensic pathology study of wound age estimation in human spleen rupture[J];Chinese Journal of Clinical and Experimental Pathology;2012-05
9 SONG Jing1,LI Yue2(1.Department of Obstetrics and Gynaecology,The 4nd Affiliated Hospital of Harbin Medical University,150001,China.2.Daowai Division of Heilongjiang Provincial Hospital);Expression and significance of fibroblast activation protein and TGFβ_1 in normal endometrium and endometrial carcinoma[J];Chinese Journal of Clinical Healthcare;2010-05
10 CAO Cui-Ping, WU Xiao-Feng+* (College of Animal Sciences,Zhejiang University,Hangzhou 310029,China);Production of Human Vascular Endothelial Growth Factor in Silkworm by Using a Recombinant Baculovirus[J];Chinese Journal of Biochemistry and Molecular Biology;2005-02
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