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《Journal of Harbin Medical University》 2012-01
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Expression of heat shock protein 70 induced by norepinephrine preconditioning on cardiomyocytes

LU Fang-hao,HU Yong-bo,WU bo,ZHAO Ya-jun,ZHANG Wei-hua,LIU Li,LI Quan-feng(Department of Pathophysiology,Harbin Medical University,Harbin 150081,China)  
Objective To investigate the expression of heat shock protein 70(HSP70) induced by norepinephrine preconditioning on cardiomyocytes.Methods The neonatal rat cardiomyocytes were cultured.The cardiomyocytes were divided into 3 groups.Control group: The cells were cultured for 72 h,without any treatment.Hypoxia/Reoxygenation group(H/Re): The cells were cultured for 3 h.In hypoxia incubator(which contained 95%N 2.5%CO2) and reoxygenation for 6 h.Norepinephrine+Hypoxia/reoxygenation group(NE+H/Re): Prior to hypoxia,the cells were treated by 100 nmol/L NE.The other procedures were the same Hypoxia/reoxygenation group.The expressions of HSP70 and bcl-2 were detected and the apoptotic rate was tested.Results The expressions of HSP70 and bcl-2 were increased in NE+ Hypoxia/reoxygenation group compared with that in Hypoxia/Reoxygenation group.The apoptotic rate of NE+ Hypoxia/reoxygenation group was lower than that of Hypoxia/Reoxygenation group.Conclusion NE preconditioning can induce the expression of HSP70,which protects hypoxia cardiomyocytes.
【Fund】: 黑龙江省教育厅资助项目(11511224)
【CateGory Index】: R363.2
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