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《Journal of Harbin Medical University》 2012-01
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Effects of methoxychlor exposure on the expression of ERα mRNA in mice placenta during early pregnancy

WANG Xiao-rong,YUAN Hong-fei,CHE Li-ping(Department of Gynaecology and Obstetrics,Heilongjiang Provincial Corps Hospital,Chinese People's Armed Police Force,Harbin 150076,China)  
Objective To investigate the effects of methoxychlor(MXC) exposure on the expression of estrogen receptor α(ERα) mRNA in mouse placenta during early pregnancy.Methods Pregnant mice were randomly divided into three groups with 10 for each,in which subcutaneous injection of MXC as the exposure group,subcutaneous injection of sesame oil as the normal control group,and subcutaneous injection of estradiol(E2) as a positive control group.Placenta tissues were obtained from each group for analysis of ERα mRNA expression by using semi-quantitative reverse transcription polymerase chain reaction(RT-PCR).Results The expression of ERα mRNA were significantly different between the MXC exposure group(0.68±0.11)and the normal control group(0.49±0.09),P0.05;and was not different between the MXC exposure group and the positive group(0.60±0.10),P0.05.Immunohistochemistry showed that the expression of ERα in pregnant mice placenta exposed to MXC was significantly higher than that in the normal control group.Conclusion The high expression of ERα may be one of the toxic mechanisms involved in the effects of MXC on embryonic development.
【CateGory Index】: R114
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Xiao-Rong,CHEN Bi-Liang,MA Xiang-Dong,CHANG FeiDepartment of Obstetrics and Gynaecology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Reproductive and developmental toxi-city of methoxychlor in pregnant mice and their foetuses[J];Journal of the Fourth Military Medical University;2007-07
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 GAO Miao,CHEN Bi-Liang,MA Xiang-DongDepartment of Obstetrics and Gynaecology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Effect of Methoxychlor on in vitro maturation of mouse oocytes[J];Journal of the Fourth Military Medical University;2008-10
2 ZHI Yun-Guo,MA Xiang-Dong,CHEN Bi-Liang Department of Obstetrics and Gynecology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Effects of methoxychlor on Calbindin-D9k gene expression in mouse uterus during implantation period[J];Journal of the Fourth Military Medical University;2009-14
3 GONG Hai-Dan,CHEN Bi-Liang,ZHANG Jian-Fang,MA Jia-Jia Department of Obstetrics and Gynaecology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Effects of methoxychlor on bone loss(osteroporosis) in mice[J];Journal of the Fourth Military Medical University;2009-24
4 Hu Meng-sang,Chen Yi-fei,Xu Ying Medical College of Jiaxing University,Jiaxing 314001,Zhejiang Province,China;Effects of environmental hormone on embryonic development[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-11
5 WANG Xiaorong1,YUAN Hongfei1,WANG Lina2,and YU Bo3.1.Department of Gynaecology and Obstetrics,Heilongjiang Provincial Corps Hospital,Chinese People's Armed Police Forces,Harbin 150076,China;2.Department of Gynaecology,General Hospital of Chinese People's Armed Police Forces,Beijing 100039,China.3.Red Cross Center hospital of Harbin,Harbin 150070,China.;Effects of methoxychlor exposure on expression of ERα mRNA in mouse placenta during early pregnancy[J];Medical Journal of the Chinese People's Armed Police Forces;2012-01
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WEN Jian-guo 1, ZHAO Guo-jun 1, TANG Guo-hua 2,et al(Department of Histology and Embryology,Xiangya School of Medicine, Central South University,Changsha 410013,Hunan,China;Medical College of Nanhua University,Hengyang 421001,Hunan,China);The Effects of Methoxychlor on Cell Cycle of Germ Cell in Male Mice[J];Journal of Elinical Research;2004-12
2 TANG Guo-hua~1,TANG Chao-ke~2,HE Xiu-sheng~(2),HE Shu-ya~3(The Center of Scientific Research and Experiment,Nan Hua University,Hengyang Hunan 421001,China);Effect of methoxychlor on toxicity of germ cell in male rat[J];Journal of Health Toxicology;2005-04
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