Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Harbin Medical University》 2012-01
Add to Favorite Get Latest Update

Research of the relationship between polymorphisms of DNA repair gene XRCC3 and endometriosis

ZOU Li-hong1,XU Shuai2,LU Mei-song1(1.Department of Gynecological Endoscopy,The First Affiliated Hospital of Harbin Medical University Harbin 150001,China;2.Department of Gynecology and Obstetrics,The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)  
Objective To investigate the association of the polymorphisms in DNA repair gene XRCC3 with endometriosis risk.Methods The polymorphisms of DNA repair gene XRCC3 between endometriosis patients and controls were detected and whether XRCC3 were associated with the severity of endometriosis or not was evaluated.Genotypes of XRCC3 were analyzed by PCR-RELP.Results There was significantly difference between endometriosis and control groups of XRCC3 genetic polymorphism(P0.05).The expression of Thr/Met gene was significantly enhanced in endometriosis(P0.05).There was not association between the distributions of genotypes or alleles of XRCC3 and the stage of endometriosis.Conclusion Patients with XRCC3 Thr/Met or Met allele genotype have susceptibility to endometriosis,but the genotype is not associated with the stage of endomtriosis.
【CateGory Index】: R711.71
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved