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《Journal of Harbin Medical University》 2013-01
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Changes of myeloperoxidase in atrial tissues of dogs with chronic atrial fibrillation

DONG Sheng1,JIA Shu-fen2,XIAO Lie3(1.Department of Cardiothoracic Surgery,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2.Department of Anesthesia,The Fifth Daqing Hospital,Daqing 163700,China;3.Department of Normal Surgery,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)  
Objective To investigate the changes and significance of myeloperoxidase(MPO) in atrial tissues of dogs with chronic atrial fibrillation.Methods Twenty mongrel dogs were randomly divided into atrial fibrillation group(n=10) and control group(n=10).The High frequency pacing was performed in atrial fibrillation group with permanent pacemaker,but not in the control group.Twenty-four weeks after pacing,atrial tissue was taken.The contents of MPO content and 3-chlorotyrosine were measured by ELISA and stable isotope dilution liquid chromatography with on-line tandem mass spectrometry,respectively.The collagen volume fraction(CVF) and activities of matrix metalloproteinase-2 and 9(MMP2,MMP-9) were determined by Masson staining and gelatin zymography,respectively.Results The levels of MPO,3-chlorotyrosine,CVF and activities of MMP-2 and MMP-9 were significantly higher in atrial fibrillation group than those in control group(P0.05).The MPO content was significantly correlated with CVF(P0.05).Conclusion MPO is possibly one of important mediators mechanistically involved in the initiation and perpetuation of chronic atrial fibrillation.
【Fund】: 黑龙江省卫生厅科研项目(2007-432)
【CateGory Index】: R541.75
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