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《Central China Medical Journal》 2001-01
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Detection of Coxsackievirus B specific IgM and IgG of the latent-chronic keshan disease patients.

Huang Hanju 1,Huang Zhenwu,Liu Jianjun 1. 1Department of Microbiology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030  
Objective To study the relationship between the infection of Coxsackieviurs B (CoxB) and the development of keshan disease. Methods Thirty patients with latent chronic keshan disease in the endemic areas were investigated. The sensitive and specific enzyme linked immunoassay was used to detect CoxB 1~6 IgM and CoxB 1~6 IgG in the sera from the patients.Results The positive rate for the CoxB 1~6 IgM antibody in the latent chronic keshan patients was significantly higher than that in the control group from non endemic area ( P 0.05 ). There was no significant difference in CoxB 1~6 antibody positive rate between the latent chronic keshan disease group and the control group from non endemic area ( P 0.05 ).Conclusion The infection of CoxB existed in endemic area of latent chronic keshan disease.
【Fund】: 卫生部科学研究基金!资助项目 (No .98-1-0 6 6 )
【CateGory Index】: R542.3
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