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《Central China Medical Journal》 2003-01
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Cell apoptosis and changes of ultrastructnre in psoriasis.

Zhou Liping, Yang Mulan , Jiang Tao et al. Department of Dermatology, Wuhan First Hospital, Wuhan 430022  
Objective To investigate the mechanism of apoptosis in psoriasis. Methods The apoptosis in psoriasic lesions and keratinocytes stimulated by psoriatic leucocytes was detected by TUNEL asssy. The ultrastructural changes were observed by transmission electron microscopy. Results The apoptosis expression was 89.31 ± 27.23 in the psoriatic lesions and 18.72 ± 8.74 in the control group (P0.01). The apoptosis expression in the keratinocytes stimulated by psoriatic leucocytes was 0.9585± 0.3421 .significantly higher than in the control group (P0.01). Ultrastructurally, there were neuclear hyperplasia of keratinocytes and loose connection between keratinocytes. Conclusion The increase of apoptosis and hyperplasia of keratinocytes may be one of protecting mechanisms to maintain stability of cell dynamics of body. Overexpression of apoptosis may be related with induction by peripheral blood leucocytes in the patients with psoriasis.
【CateGory Index】: R758.63
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