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Effects of an osteogenic peptide on biomechanical properties during fracture healing

TENG Yu,Peng Hai-bo,Peng Ming-gang,et al.Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China  
Objective To determine the effects of a synthetic peptide with osteogenic activity on the biomechanical properties during femoral fracture healing in a mouse model,and to evaluate the capacity of P24 to enhance bone repair.Methods Sixty 8-week-old female C57BL/6 mice were randomly assigned into two groups(n=20 each): phosphate buffered saline group and osteogenic peptide group.In a murine femur fracture model,collagen scaffolds loaded with buffer or osteogenic peptide were implanted into the site of fractured femur respectively.Fracture healing was studied using three-point bending test at 3rd week after fracture,and the changes in the maximum load,elastic load,maximum flexure,elastic flexure,maximum stress and flexure modulus of all femoral samples were observed.Results Treatment with osteogenic peptide resulted in significant increases in all biomechanical parameters(P0.01) compared to PBS controls.Conclusion Synthetic peptide with osteogenic activity has a beneficial effect on the biomechanical function of regenerating bone.
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