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An experimental research on the repair of bone defect with allograft embedded by vascularized periosteum flap

ZHANG Da-wei,TIAN Qing-ye,LIU Guang-jun,et al.Weifang Medical University,Weifang 261042,China  
Objective To study the effect of cortical windowing bone allograft embedded by vascularized thin cortex-periosteum flap to repair massive bone defect.Methods The adult rabbit model of massive tibial defect was established and reconstructed with allograft from de-antigenic rabbit tibia.In experimental group,the cortical windowing grafts were embedded by vascularized thin cortex-periosteum flap,while in other models using vascularized flap packing the allografts directly as the control group.X-ray examination was taken for each graft post-operatively.Histological observation(H-E stain) and immunohistochemical examination(VEGF) were done on the bone and the surrounding tissues.Results In the experimental group callus formation and transformation remodeling of the bone defects,neovascularization invasion into the defect,new bone formation and mature of the bone units were earlier than in the control group.Conclusion The healing model of bone allograft embedded by vascularized thin cortex-periosteum flap is a good way to repair massive bone defect,and it has significant advantages over the directly packing model.
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