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《Journal of Huazhong Agricultural University》 2013-01
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Pharmacokinetics and elimination regularity of florfenicol and florfenicol amine,in rice field eel(Monopterus albus)

XIE Ling-ling WU Zhi-xin YUAN Juan LIU Jia-jia PENG Xiao-yun ZHU Xu CHEN Xiao-xuan College of Fisheries,Huazhong Agricultural University,Wuhan 430070,China  
The aim of this study was to evaluate the pharmacokinetics of florfenicol(FF) and its metabolite,florfenicol amine(FFA),after oral(p.o.) administration and investigate their depletion after multiple oral administrations for 3 consecutive days in rice field eel(Monopterus albus) at 25 ℃.After p.o.administration of 20 mg/kg,the peak concentration of FF(Cmax) and time to reach FF peak concentration(Tmax) in plasma,liver,kidney and muscle were 6.07 mg/L,7.57 mg/kg,9.34 mg/kg,5.87 μg/mg and 3.67 h,4.45 h,2.01 h,9.28 h,respectively.The order of t1/2β was kidney(29.26 h)liver(19.32 h)muscle(17.22 h)plasma(10.84 h).FFA was also found in all tissues with a lower concentration than FF after p.o.administrations throughout the study.The longest t1/2β of 45.93 h and the largest metabolic rate(MR) of 49.21% were observed in kidney.After multiple oral doses(20 mg/(kg·d) for 3 d),the highest residues was observed in kidney,next in liver and then in muscle.The residues was undetectable in all tissues after 10 d which was similar to the former 12 d withdrawal time to ensure that the residues of florfenicol are less than the maximal residue limit of tolerance established by Japan.
【Fund】: 国家科技支撑计划项目(2007BAD37B02);; 湖北省“十一五”科技攻关项目(2006AA203A02、2007AA203A01);; 华中农业大学研究生教育创新工程基金
【CateGory Index】: S948
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【Citations】
Chinese Journal Full-text Database 7 Hits
1 ZHU Ze-yao,ZHANG Qi-zhong,YU Xiang-man,FAN Zhen-yan,YE Bo-xi(Institute of Hydrobiology,Jinan University,Guangzhou 510632);Study on Pharmacokinetics of Norfloxacin Hydrochloride in Hybrid Tilapia(Oreochromis aureus×O.niloticus)[J];Freshwater Fisheries;2008-01
2 YU Pei-jian~1,WENG Zu-tong~1,FAN Hai-ping~1,YU Dao-jin~2,CHEN Xing~3(1.The Freshwater Fisheries Research Institute of Fujian Province,Fuzhou 350002,China2.Animal Scenices College of Agriculture and Forest University of Fujian,Fuzhou 350002,China);Pharmacokinetics of Florfenicol in European eel[J];Journal of Fujian Fisheries;2005-04
3 PAN Hong-yan,GONG Zhi-yong(College of Food Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,China);Advance in the Research and Clinical Application of Florfenicol[J];Hubei Agricultural Sciences;2011-02
4 PAN Hong-yan1,YANG Hu1,GUO Jiao-jiao1,GONG Zhi-yong1,LI Gu2(1.College of Food Science and Engineering Wuhan Polytechnic University,Wuhan 430023,China; 2.Yangtze River Fisheries Research Insitute,Chinese Academy of fishery Science,Jingzhou 434000,Hubei,China);Acute Toxicity Test of Florfenicol in Sturgeon[J];Hubei Agricultural Sciences;2011-04
5 LIN Mao1,2,WANG Xue-hong1,2,YAO Zhi-xian1 (1.Fisheries College,Jimei University,Xiamen 361021,China;2.Key Laboratory of Science and Technology for Aquaculture and Food Safety(Jimei University),Fujian Province,Xiamen 361021,China);Residue and Elimination of Florfenicol in Eels Anguilla japonica and A. anguilla[J];Journal of Jimei University(Natural Science);2011-02
6 YUE Gang-Yi,WU Zhi-Xin,YANG Qian,QU Yi,PANG Li-Jiao,XIE Ling-Ling,YU Yan-Mei and CHEN Xiao-Xuan(College of Fisheries,Huazhong Agricultural University,Wuhan 430070);PHARMACOKINETICS OF FLORFENICOL AND ITS METABOLITE,FLORFENICOL AMINE,IN RED SWAMP CRAYFISH,PROCAMBARUS CLARKII[J];Acta Hydrobiologica Sinica;2011-02
7 JIAN Ji-chang,WU Zao-he,CHEN Gang (Fisheries College of Zhanjiang Ocean University, Zhanjiang 524025,China);Pharmacokinetics of Enrofloxacin in Sciaenops ocellatus[J];Chinese Journal of Veterinary;2005-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIN Mao et al (Fisheries College,Jimei University,Xiamen,Fujian 361021);Pharmacokinetics of Florfenicol in A.japonica and A.Anguilla[J];Journal of Anhui Agricultural Sciences;2011-36
2 QIAN Yun-Yun TANG Jun ZHENG Zong-Lin YANG Xian-Le(Aquatic Pathogen Collection Center of Ministry of Agriculture,Shanghai Fisheries University,Shanghai 200090,China);Pharmacokinetics of Enrofloxacin in Macrobrachium rosenbergii[J];Chinese Journal of Zoology;2007-05
3 PAN Hong-yan1,GUO Jiao-jiao1,YANG Hu1,GONG Zhi-yong1,LI Gu2(1.College of Food Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,China;2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Jingzhou 434000,China);Pharmacokinetics of a Chemical Florfenicol in Sturgeon[J];Fisheries Science;2011-07
4 LIU Gui-ying1,WAN Li 2,GE Kun3,WANG Nian-bin1,SONG Yong-gang1,YANG-bin4(1.Liaoning Ocean and Fisheries Science Research Institute,Dalian 116023,China;2.Dalian Ocean University,Dalian 116023,China;3.Dalian Ocean School,Dalian 116023,China;4.Dalian Petrochemical Corporation,PetroChina Dalian 116031,China);Detecion of Fluoroquinolone Residues in Kuruma Shrimp Marsupenaeus japonicus by Ion-Pair HPLC[J];Fisheries Science;2011-11
5 WANG Wei-li,LUO Li,JIANG Lan,TAN Ai-ping,ZOU Wei-min,LU Mai-xin(Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou 510380,China);Pharmacokinetics of florfenicol in tilapia fed diet containing the drug[J];Journal of Dalian Ocean University;2010-04
6 GUO Jiao-jiao1,PAN Hong-yan1,YANG Hu1,LIAO Xin1,GONG Zhi-yong1,LI Gu2(1.College of Food Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,China;2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Jingzhou 434000,China);Pharmacokinetics of enrofloxacin in sturgeon Acipenser schrenckii[J];Journal of Dalian Ocean University;2011-04
7 FAN Zhen-yan1,ZHANG Qi-zhong1,3,CHEN Guo-quan2,GAN An-hui2,YU Xiang-man1,ZHU Ze-yao1(1.Institute of Hydrobiology,Jinan University,Guangzhou 510632;2.Agrotechnical Popularization Center of Baiyun District in Guangzhou,Guangzhou 510405;3.Key laboratory of Aquatic science of Chongqing,Key laboratory Eco-environments in Three Gorges Reservoir Region(Ministry of Education),Chongqing 400715);Residue Elimination of Norfloxacin Hydrochloride in Hybrid Tilapia(Oreochromis aureus×O.niloticus)[J];Freshwater Fisheries;2008-06
8 CHEN Ben-liang,ZHANG Qi-zhong,YU Xiang-man (Institute of Hydrobiology,Jinan University,Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering Ministry of Education, Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institutes,Guangzhou 510632);Bioavailability of norfloxacin hydrochloride in hybrid tilapia(Oreochromis aureus×O.niloticus)[J];Freshwater Fisheries;2011-03
9 LUO Ya-jin,SUN Yong-xue,ZENG Dong-ping,YANG Da-wei,SUN Jian (Laboratory of Veterinary Phamacology,South China Agricultural University,Guangzhou,Guangdong,510642,China);Pharmacokinetics and Bioavailability of Enrofloxacin Microcapsules in Pigs[J];Progress in Veterinary Medicine;2010-10
10 LIAO Bi-chai1,2(1.The Freshwater Fisheries Research Institute of Fujian Province,Fuzhou,Fujian 350002,China; 2.Fujian Fishery Technical Extension Center,Fuzhou,Fujian 350003,China);Pharmacokinetics and Residues of Norfloxacin in Hybrid Tilapia[J];Fujian Journal of Agricultural Sciences;2011-06
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 GUO Chuang,ZHU Guoqiang,WANG Yongkun,ZHUANG Guohong,ZHOU Jihong(College of Animal Husbandry and Veterinary Medicine,Yangzhou University,Yangzhou,225009);Isolation,Identification and Selective Test for the Best Curative Medicine on Fourteen Strains of Aeromonas.sp from Infected Aquatic Animals[J];Fisheries Science;2003-04
2 YE Su-lan,YU Zhi-ping(Zhejiang Ocean University,Xiaoshan 311258,China);Acute Toxicity of Six Fishery Drugs to Grass Carp Juveniles[J];Fisheries Science;2007-10
3 MU Zhimei SU Zhenxia XIAO Hui(Forestry College of Shandong Agriculture University Taian 271018);Pharmacokinetics of Norfloxacin·HCl in Silkworms[J];Acta Sericologica Sinica;2004-01
4 XU Li-wen~(1), LIAO Chang-rong~(1,2), LIU Guang-feng~(1),WANG Jiang-yong~1(1.South China Sea Fisheries Research Institue,Chinese Academy of Fishery Sciences,Guangzhou 510300,China;2.School of Life Science and Technology,Shanghai Fisheries Univ,Shanghai 200090,China);Acute toxicity and histological toxicology of florfenicol to abalone Haliotis diversicolor Reeve[J];Journal of Dalian Fisheries University;2005-04
5 LIU Xiao-qiang1,LIU Hai-xia2,LIANG Tuo1,LIANG Xin-xin1(1.College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi,712100,China;2.College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi,712100,China);Acute Toxicity of Four Antibacterial Drugs on Carassius auratus Fries[J];Progress in Veterinary Medicine;2010-01
6 YU Pei-jian~1,WENG Zu-tong~1,FAN Hai-ping~1,YU Dao-jin~2,CHEN Xing~3(1.The Freshwater Fisheries Research Institute of Fujian Province,Fuzhou 350002,China2.Animal Scenices College of Agriculture and Forest University of Fujian,Fuzhou 350002,China);Pharmacokinetics of Florfenicol in European eel[J];Journal of Fujian Fisheries;2005-04
7 Xiubo LiShiboLiangping (Feed Research Institute of Chinese Academy of Agricultural Sciences,Beijing 100081);A New Broad Spectrum AntibioticFlorfenicol[J];ANIMAL SCIENCE ABROAD;1999-03
8 LIU De ping 1,YANG Jun 2 (1.Yaan Sanjiu Pharmacia Corporation,Yaan 625000,China; 2.The second institute of CAAC,Chengdu 610041,China);DETERMINATION OF ENROFLOXACIN IN ANIMAL PLASMA BY REVERSED-PHASE ION-PAIR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY[J];Chemical Research and Application;2001-01
9 LI Jing-yun1,2 , LI Jian1 , WANG Qun1, ZHAN Wen-bin2 Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Science, Qingdao 266071,China; 2. Fishery College, Ocean University of China, Qingdao 266003,China);Single dose pharmacokinetics of florfenicol in Fenneropenaeus chinensis[J];Marine Sciences;2006-07
10 LIU Xiu-hong LI Jian WANG Qun Yellow Sea Fisheries Research Institute, Qingdao 266071 Ocean University of China, Qingdao 266003;Studies on residues and depletion of norfloxacin in Bastard halibut (Paralichthys olivaceus) in vitro[J];Marine Fisheries Research;2003-04
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