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《Journal of China West Normal University(Natural Sciences)》 2012-03
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Research about the Joint Effect of Taxol and Resveratrol on Human Liver Cancer HepG-2

GENG Wen-feng1,WU Chun-lian1,2, CHEN Yang-qiong1,ZHANG Si-nan1,SUN Jing-hui1(Key Laboratory of Southwest China Wildlife Resources Conservation,China West Normal University, Nanchong 637009,P.R.China)  
Paclitaxel and resveratrol are two common anti-cancer drugs that have proved effective in clinical trials.In this study,we investigated the independent effect of the two drugs as well as their combined effect on the viability of HepG-2 cells,trying to elucidate the joint effect of the two drugs.The independent and combined effects of the two drugs on HepG-2 at various concentrations were measured by CCK-8 assay;inhibitory rates and IC50 were calculated and efficacies were judged according to the Revised Jin's Formula.Both paclitaxel and resveratrol showed strong inhibitory effect on HepG-2 cells and at the tested concentration the inhibitory rates were up to 45.81%-81.80% and 34.43%-96.30% respectively,showing an obvious dose-dependency.The two drugs showed combined effects when used together at the concentration of 5-20μmol/L for paclitaxel and 100-1000μmol/L for resveratrol.And their IC50 were also decreased from 1.47μmol/L and 122.07μmol/L when used independently to 0.65μmol/L and 42.41μmol/L when used together.Our results confirmed that combination use of paclitaxel and resveratrol can significantly enhance their anti-cancer effect,that is to say,the two drugs have synergy effect.
【Fund】: 三峡库区生态环境与生物资源省部共建重点实验室开放课题基金项目(SKL-2011-05)
【CateGory Index】: R735.7
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 PAN Hong-ming1,FEI Hong-xin1,HUANG Xiao-yi2(1Departerment of Biochemistry,Qiqihaer Medical College,Qiqihaer 161042,China;2Departerment of Genetics,Harbin Medical University,Harbin 150086,China);Effect of combination of paclitaxel and resveratrol on human gastric carcinoma cell strain MGC803 in vitro[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 LI Chun-sheng1,LIU Tong-jun1,JING Xia-bin2,CHEN Xue-si2,XU Xiao-yi2,YU Hui-qiu3(1.Department of Anorectal Surgery,First Hospital,Jilin University,Changchun 130021,China;2.Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;3. Department of Rehabilitation,China -Japan Union Hospital,Jilin University,Changchun 130033,China);Inhibitory effects of paclitaxel slowly released by PLLA-PEG750 ultrafine fibers on SKOV3 cell line[J];Journal of Jilin University(Medicine Edition);2008-04
2 LIU Zhong-da,YUAN Zhou-xin,ZHANG Zun-jing,LI Quan(Lishui TCM Hospital of Zhejiang Province,Lishui 323000,China);Inhibitory effect of extract of Chimonanthus salicifolius on SGC-7901 cell and the possible mechanism[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-10
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6 FAN Yu-han,LUO Cong-yan,CHEN Wen(Key Laboratory of Xinjiang Phytomedicine Resources,Ministry of Education,Xinjiang Shihezi 832000,China);Synergistic action of combination of glabridin and fullereneols on inhibition of tyrosinase and ability of scavenging DPPH·[J];Chinese Journal of Hospital Pharmacy;2011-21
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