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《Chinese Journal of Disease Control & Prevention》 2017-06
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Herpes simplex virus 2 infection is associated with adverse prognosis for ischemic stroke

ZHANG Pei-pei;HUANG Ping;GUO Yu-mei;LV Li-ying;ZHOU Mo;LONG Zhen-hai;ZHANG Yong-hong;XU Tan;Department of Epidemiology and Health statistics,School of Public Health,Medical College of Soochow University;Department of Prevention and Health,Minghuang Community Health Service Center,Hutang Town,Wujin District,Changzhou;Clinical Laboratory,People's Hospital of Xing'an meng;Department of Science and Education,Suzhou Municipal Hospital;Department of Neurology,Fuxin Central Hospital;  
Objective To examine the association between herpes simplex virus type 2( HSV-2) infection and the adverse prognosis at 14 days( or discharge) after onset of ischemic stroke. Methods A cohort study of 1150 ischemic stroke cases was conducted,who were from 14 hospitals with confirmed diagnosis and blood HSV-2 Ig G tested. Adverse prognosis was defined with death or onset of cardiovascular events after 14 days( or discharge). Logistic regression was applied to estimate the association between HSV-2 and adverse prognosis. Results HSV-2 Ig G was classified with quartile.First quartile was used with reference,after multiple factors adjusted,fourth quartile was 4. 32-fold risk to first quartile( P= 0. 015),the risk was increased with the level elevated in quartile groups. Subgroup analysis showed that elevated HSV-2Ig G increased the risk of adverse prognosis among cases in female,or non-drinking,or with diabetes,or with hypertension( all P 0. 05). Conclusions In ischemic stroke with HSV-2 infection,elevated HSV-2 Ig G may increase the risk of adverse prognosis at 14 days( or discharge) after onset of ischemic stroke,the risk may increase with the HSV-2 Ig G level elevated.
【Fund】: 国家自然科学基金(81172760)
【CateGory Index】: R743.3;R752.11
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1 YOU Xiao-ling;HU Shu-fen;SUN Ling;CHEN Qiu-lian;Hemodialysis Center, the 8th Affiliated Hospital of Sun Yat-Sen University;;Effect of Collaborative Care Model on Self-care Ability and Treatment Compliance in Hemodialysis Patients[J];护理学报;2017-14
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