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《Basic & Clinical Medicine》 2009-07
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Regulatory mechanisms of PTEN

HONG Jun-bo,LU·· Nong-hua*(Department of Gastroenterology,the First Affiliated Hospital,Medical College of NanChang University,Nanchang 330006,China)  
PTEN(Phosphatase and Tensin Homology deleted from Chromosome ten),a putative antioncogene,encodes a PTEN protein that has a dual specificity phosphatase activity with both protein phosphatase and lipid phosphatase,which regulates a variety of molecules through inhibiting the PI3K/Akt signaling pathway.Recently,some scholars dedicate to the modulation of PTEN,which demonstrates that PTEN can be regulated by multiple factors at the level of gene and protein.This review briefly summarizes up-to-date information about the modulation of PTEN and its mechanisms.
【Fund】: 江西省自然基金(0540070)
【CateGory Index】: R730.2
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