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Screening of Anti Platelet and Anti Atherosclerotic from Chinese Medicines

Zheng Yinan et al. (Colle.of Chin. Medi. Material, Jilin Agri. Univ., Changchun 130118)  
In platelets, cyclooxygenase and lipoxygenase catalyze the initial reactions for the formation of two major arachidonic acid metabolites, thromboxane B 2 (TXB 2), 12 hydroxy 5,8,10,14 eicosatetraenoic acid (12HETE). The cyclooxygenase mediatel production of TXA 2, am active form of TXB 2, induce platelet aggregation, and the lipoxygenase reaction is also involved in atherosclerotic and allergy process. Therefore, a specific inhibtor of cyclooxygenase and lipoxygenase should be useful as a therapeutic drug for treating thromobsis and atherosclerosis. In the present work we studied on effect of arachidonic acid metabolism in rabbit platelets by Chinese medicines with radio chromatography and found that 23 Chinese medicines had a selective inhibitory effect on these enzymes. In Cinnamomam japonicum Sieb, Rhus Chinensis Mill, Foeniculum vilgare mill, Ribes nigrum L. Taraxacum mongolicum Hand Mazz, Glycyrrhiza uralensis Gischer, Salix babylonica L. and plantago asiatica L. the ether soluble material(10mg/L) had strong inhibitory activity against cycloogenase or lipoxygenase.
【Fund】: 吉林省科委发展项目资助
【CateGory Index】: R284.1
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