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Impact of β-lactamases on the clinical use of β-lactam antibiotics

WANG Xue wen (Department of Hematology,Jinling Hospital,Nanjing 210002,China)  
lactamase production is a very common mechanism of antibiotic resistance.The impact of β lactamases on the clinical use of β lactam antibiotics depends on the spectrum of activity of the enzymes.The β lactamases can be divided into four classes(A,B,C and D) in Bush's classification and Frere's classification,the class A inclusing extended spectrum β lactamases and class C β lactamase generally have the most impact on clinical practice.Master classification of bacterial β lactamases and characteristics of regional prevalence of bacteria producting β lactamases that can play the major impact to therapeutic effect of β lactam antibiotic and selection of antiobics.
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