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Estimating concentrations of serum total digoxin and digoxin-like immunoreactive substances in patients of cardiac failure with renal insufficiency

Li Jinheng; Wu Zhenguo; Ling Shusheng;et al(①Department of Clinical Pharmacology,Jinling Hospital Nanjing,210002)  
The concentrations of serum total digoxin and digoxin-like immunoreactive substances(DLIS)in twelve patients of cardiac failure with renal insufficiency were estimated after determination of free digoxin by ultrafiltration with fluorescence polarization immunoassay.In these patients,determinedfree digoxin concentration in serum was 0.79 ±0.48(0.46~2.10)nmol/L,Determined total digoxin(1.31±0.80nmol/L)was significantly higher than calculated total digoxin(1.05±0.64 nmol/L)(P0.01 ),suggesting the presence of elevated DLIS in serum for these patients,Calculated DLIS concentration was 0.27 ±0.19(0.07~0.76)nmol/L,The results were well consistent with that obtained by re-cently published method of Dasgupta et al.
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