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Study on pharmacokinetic and bioavailability of roxithromycin capsule and granule

Zhuo Haitong;Chu Xiaoman; Cao Wen;et al(Department of Clinical Pharmacology,Jinling Hospital Nanjing,210002)  
The pharmacokinetics and relative bioavailabiliy of roxithromycin capsule and granule were investigated after oral administration of 300 mg in 10 healthy volunteers.The drug were rapidly absorbed after administration.The peak plasma levels(Tmax)following 300 mg single doses accured about two hours.The peak concentration(Cmax)of roxithromycin tablets,capsule and granule were≥7.0mg/L.The elimination plasma half-life(t1/2β))is approximately 13h.The relative bioavailability of roxithromycin capsule and granule were 95.4%and 98.99%,respectively.
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