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Study on the changes of catecholamine of rat brains in the experimental reversible global ischemia and reperfusion

Chen Guanghui; Rao Mingli(Department of Neurology,Jinling Hospital Nanjing,210002)  
Contents of DA,NE and E in hippocampus,thalamus,striatum and neocortex of Wistar rat brains were assayed by high-performance liquid chromatography with electrochemical detector during 15 min global ischemia and different periods of postischemic reperfusion.The results showed that there were metabolic disorders in the zones of selective ischemic vulnerability,especially in hippocampus and striatum.We considered that CA played a major role in mediating selective neuronal damage.That the NE content in hippocampus and the DA con tent in striatum increased during ischemia was a key event of pathophysiology,The decreased contentsof NE or DA after reperfusion might imply the severity of neuronal dysfunction or neuronal necrosis.In addition,CA might cooperate with EAAs,which amplified the pathological role of CA.
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