Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

The expression and significance of FAK and NF-kBp65 in hepatocellular carcinoma after transcatheter arterial chemoembolization

WANG Hui-wen, LIU Rui-bao, LIU Yan, SHEN Hai-yang, YANG Yi, SUN Hou-bin, LI Kai. Department of Interventional Radiology, the Third Affiliated Hospital, Harbin Medical University, Harbin 150086, China  
Objective To investigate the expression and significance of FAK and NF-KBp65 in the residual tumor tissues of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods The surgical specimens of HCC after TACE were colleted in 28 cases (TACE group), and surgical specimens of HCC without having received any other treatments were obtained in 30 cases (pure surgery group). The expression of FAK and NF-KBp65 in the residual tumor tissues was determined by using immunohistochemical SP method. Results The positive rate of FAK expression in TACE group was 75.0%, which was much higher than that in pure surgery group (46.7%), and the difference between the two groups was statistically significant (P 0.05). The positive rate of NF-KBp65 expression in TACE group was 78.6%, which was 53.3% in pure surgery group, and the difference between the two groups was statistically significant (P 0.05). In TACE group the FAK expression in residual cancerous tissues showed a positive correlation with the expression of NF-KBp65 (r = 0.503, P = 0.006). Both the number of performing TACE and the Lipiodol deposition pattern classification showed no statistically significant correlation with the expression of FAK or NF-KBp65 (P 0.05). Conclusion The expression of FAK and NF-KBp65 in the residual cancerous tissues of hepatocellular carcinoma after transcatheter arterial chemoembolization is markedly increased. The higher expression of FAK and NF-KBp65 may be one of the main reasons for high recurrence rate after TACE. (J Intervent Radiol, 2011, 20: 621-624)
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved