Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

A new cerebral vasospasm model established with endovascular puncture technique

TU Jian-fei, LIU Yi-zhi, JI Jian-son, ZHAO Zhong-wei. Department of Radiology, Lishui Municipal Central Hospittd, Lishui, Zhejiang Province 323000, China  
Objective To investigate the method of establishing cerebral vasospasm (CVS) models in rabbits by using endovascular puncture technique. Methods Endovascular puncture procedure was performed in 78 New Zealand white rabbits to produce subarachnoid hemorrhage (SAH). The survival rabbits were randomly divided into seven groups (3h, 12h, 1d, 2d, 3d, 7 d and 14 d), with five rabbits in each group for both study group (SAH group) and control group. Cerebral CT scanning was carried out in all rabbits both before and after the operation. The inner diameter and the thickness of vascular wall of both posterior communicating artery (PcoA) and basilar artery (BA) were determined after the animals were sacrificed, and the results were analyzed. Results Of 78 experimental rabbits, CVS model was successfully established in 45, including 35 of SAH group and 10 of control subgroup. The technical success rate was 57.7%. Twelve hours after the procedure, the inner diameter of PcoA and BA in SAH group was decreased by 45.6%and 52.3%, respectively, when compared with these in control group. The vascular narrowing showed biphasic changes, the inner diameter markedly decreased again at the 7th day when the decrease reached its peak to 31.2% and 48.6% , respectively. Conclusion Endovascular puncture technique is an effective method to establish CVS models in rabbits. The death rate of experimental animals can de decreased if new interventional material is used and the manipulation is carefully performed. (J Intervent Radiol, 2011 , 20: 637-640)
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved